Risk factors for Crimean-Congo Haemorrhagic Fever (CCHF) virus exposure in farming communities in Uganda

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dc.contributor.authorAtim, Stella A.
dc.contributor.authorAshraf, Shirin
dc.contributor.authorAdemun, Anna R.
dc.contributor.authorNakayiki, Teddy
dc.contributor.authorBalinandi, Stephen
dc.contributor.authorNakanjako, Gladys
dc.contributor.authorAbaasa, Andrew
dc.contributor.authorOdongo, Steven
dc.contributor.authorEsau, Martin
dc.contributor.authorKaleebu, Pontiano
dc.contributor.authorLutwama, Julius J.
dc.contributor.authorMasembe, Charles
dc.contributor.authorLambe, Teresa
dc.contributor.authorTweyongyere, Robert
dc.date.accessioned2023-06-08T19:47:51Z
dc.date.available2023-06-08T19:47:51Z
dc.date.issued2022
dc.description.abstractCrimean-Congo Haemorrhagic Fever (CCHF) is an emerging human-health threat causing sporadic outbreaks in livestock farming communities. However, the full extent and the risks associated with exposure of such communities has not previously been well-described. We collected blood samples from 800 humans, 666 cattle, 549 goats and 32 dogs in districts within and outside Ugandan cattle corridor in a cross-sectional survey, and tested for CCHFV-specific IgG antibodies using Enzyme-Linked Immunosorbent Assays. Sociodemographic and epidemiological data were recorded using structured questionnaire. Ticks were collected to identify circulating nairoviruses by metagenomic sequencing. CCHFV seropositivity was in 221/800 (27·6%) in humans, 612/666 (91·8%) in cattle, 413/549 (75·2%) in goats and 18/32 (56·2%) in dogs. Human seropositivity was associated with livestock farming (AOR=5·68, p<0·0001), age (AOR=2·99, p=0·002) and collecting/eating engorged ticks (AOR=2·13, p=0·004). In animals, seropositivity was higher in cattle versus goats (AOR=2·58, p<0·0001), female sex (AOR=2·13, p=0·002) and heavy tick infestation (>50 ticks: AOR=3·52, p=0·004). CCHFV was identified in multiple tick pools of Rhipicephalus appendiculatus.en_US
dc.identifier.citationAtim, S. A., Ashraf, S., Belij-Rammerstorfer, S., Ademun, A. R., Vudriko, P., Nakayiki, T., ... & Tweyongyere, R. (2022). Risk factors for Crimean-Congo Haemorrhagic Fever (CCHF) virus exposure in farming communities in Uganda. Journal of Infection, 85(6), 693-701.https://doi.org/10.1016/j.jinf.2022.09.007en_US
dc.identifier.issn0163-4453
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/8907
dc.language.isoenen_US
dc.publisherJournal of Infectionen_US
dc.subjectViral Haemorrhagic Feveren_US
dc.subjectCrimean-Congo Hemorrhagic fever virusen_US
dc.subjectCCHFen_US
dc.subjectzoonotic diseaseen_US
dc.titleRisk factors for Crimean-Congo Haemorrhagic Fever (CCHF) virus exposure in farming communities in Ugandaen_US
dc.typeArticleen_US
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