Drug Tolerance in Mycobacterium tuberculosis

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dc.contributor.authorWallis, Robert S.
dc.contributor.authorPatil, Shripad
dc.contributor.authorCheon, Seon-Hee
dc.contributor.authorEdmonds, Kay
dc.contributor.authorPhillips, Manijeh
dc.contributor.authorPerkins, Mark D.
dc.contributor.authorJoloba, Moses
dc.contributor.authorNamale, Alice
dc.contributor.authorJohnson, John L.
dc.contributor.authorTeixeira, Lucileia
dc.contributor.authorDietze, Reynaldo
dc.contributor.authorSiddiqi, Salman
dc.contributor.authorMugerwa, Roy D.
dc.contributor.authorEisenach, Kathleen
dc.contributor.authorEllner, Jerrold J.
dc.date.accessioned2021-12-18T06:35:49Z
dc.date.available2021-12-18T06:35:49Z
dc.date.issued1999
dc.description.abstractAlthough Mycobacterium tuberculosis is eradicated rapidly during therapy in some patients with pulmonary tuberculosis, it can persist for many months in others. This study examined the relationship between mycobacterial drug tolerance (delayed killing in vitro), persistence, and relapse. It was performed with 39 fully drug-susceptible isolates from a prospective trial of standard short-course antituberculous therapy with sputum smear-positive, human immunodeficiency virus-uninfected subjects with pulmonary tuberculosis in Brazil and Uganda. The rate of killing in vitro was determined by monitoring the growth index (GI) in BACTEC 12B medium after addition of drug to established cultures and was measured as the number of days required for 99% sterilization. Drugs differed significantly in bactericidal activity, in the following order from greatest to least, rifampin > isoniazid-ethambutol > ethambutol (P < 0.001). Isolates from subjects who had relapses (n 5 2) or in whom persistence was prolonged (n 5 1) were significantly more tolerant of isoniazidethambutol and rifampin than isolates from other subjects (P < 0.01).en_US
dc.identifier.citationWallis, R. S., Patil, S., Cheon, S. H., Edmonds, K., Phillips, M., Perkins, M. D., ... & Ellner, J. J. (1999). Drug tolerance in Mycobacterium tuberculosis. Antimicrobial agents and chemotherapy, 43(11), 2600-2606.en_US
dc.identifier.urihttps://journals.asm.org/doi/abs/10.1128/AAC.43.11.2600
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/784
dc.language.isoenen_US
dc.publisherAntimicrobial agents and chemotherapyen_US
dc.subjectDrugen_US
dc.subjectToleranceen_US
dc.subjectMycobacterium tuberculosisen_US
dc.titleDrug Tolerance in Mycobacterium tuberculosisen_US
dc.typeArticleen_US
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