Antivenin plants used for treatment of snakebites in Uganda: ethnobotanical reports and pharmacological evidences

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dc.contributor.authorOmara, Timothy
dc.contributor.authorKagoya, Sarah
dc.contributor.authorOpeny, Abraham
dc.contributor.authorOmute, Tom
dc.contributor.authorSsebulime, Stephen
dc.contributor.authorKiplagat, Kibet Mohamed
dc.contributor.authorBongomin, Ocident
dc.date.accessioned2023-04-13T16:49:40Z
dc.date.available2023-04-13T16:49:40Z
dc.date.issued2020
dc.description.abstractSnakebite envenomation is a serious public health concern in rural areas of Uganda. Snakebites are poorly documented in Uganda because most occur in rural settings where traditional therapists end up being the first-line defense for treatment. Ethnobotanical surveys in Uganda have reported that some plants are used to antagonize the activity of various snake venoms. This review was sought to identify antivenin plants in Uganda and some pharmacological evidence supporting their use. A literature survey done in multidisciplinary databases revealed that 77 plant species belonging to 65 genera and 42 families are used for the treatment of snakebites in Uganda. The majority of these species belong to family Fabaceae (31%), Euphorbiaceae (14%), Asteraceae (12%), Amaryllidaceae (10%) and Solanaceae (10%). The main growth habit of the species is shrubs (41%), trees (33%) and herbs (18%). Antivenin extracts are usually prepared from roots (54%) and leaves (23%) through decoctions, infusions, powders, and juices, and are administered orally (67%) or applied topically (17%). The most frequently encountered species were Allium cepa, Carica papaya, Securidaca longipedunculata, Harrisonia abyssinica, and Nicotiana tabacum. Species with global reports of tested antivenom activity included Allium cepa, Allium sativum, Basella alba, Capparis tomentosa, Carica papaya, Cassia occidentalis, Jatropa carcus, Vernonia cinereal, Bidens pilosa, Hoslundia opposita, Maytensus senegalensis, Securinega virosa, and Solanum incanum. There is need to identify and evaluate the antivenom compounds in the claimed plants.en_US
dc.identifier.citationOmara, T., Kagoya, S., Openy, A., Omute, T., Ssebulime, S., Kiplagat, K. M., & Bongomin, O. (2020). Antivenin plants used for treatment of snakebites in Uganda: ethnobotanical reports and pharmacological evidences. Tropical Medicine and Health, 48, 1-16. https://doi.org/10.1186/s41182-019-0187-0en_US
dc.identifier.urihttps://doi.org/10.1186/s41182-019-0187-0
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/8459
dc.language.isoenen_US
dc.publisherTropical Medicine and Healthen_US
dc.subjectAntiophidicen_US
dc.subjectAntiveninen_US
dc.subjectSnakebiteen_US
dc.subjectTraditional medicineen_US
dc.titleAntivenin plants used for treatment of snakebites in Uganda: ethnobotanical reports and pharmacological evidencesen_US
dc.typeArticleen_US
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