Viruses in saliva from sanctuary chimpanzees (Pan troglodytes) in Republic of Congo and Uganda
dc.contributor.author | Dunay, Emily | |
dc.contributor.author | Rukundo, Joshua | |
dc.contributor.author | Atencia, Rebeca | |
dc.contributor.author | Cole, Megan F | |
dc.contributor.author | Cantwell, Averill | |
dc.contributor.author | Emery Thompson, Melissa; | |
dc.contributor.author | Rosati, Alexandra G | |
dc.contributor.author | Goldberg, Tony L | |
dc.date.accessioned | 2024-09-17T10:26:17Z | |
dc.date.available | 2024-09-17T10:26:17Z | |
dc.date.issued | 2023-06-29 | |
dc.description.abstract | Pathogen surveillance for great ape health monitoring has typically been performed on non-invasive samples, primarily feces, in wild apes and blood in sanctuary-housed apes. However, many important primate pathogens, including known zoonoses, are shed in saliva and transmitted via oral fluids. Using metagenomic methods, we identified viruses in saliva samples from 46 wild-born, sanctuary-housed chimpanzees at two African sanctuaries in Republic of Congo and Uganda. In total, we identified 20 viruses. All but one, an unclassified CRESS DNA virus, are classified in five families: Circoviridae, Herpesviridae, Papillomaviridae, Picobirnaviridae, and Retroviridae. Overall, viral prevalence ranged from 4.2% to 87.5%. Many of these viruses are ubiquitous in primates and known to replicate in the oral cavity (simian foamy viruses, Retroviridae; a cytomegalovirus and lymphocryptovirus; Herpesviridae; and alpha and gamma papillomaviruses, Papillomaviridae). None of the viruses identified have been shown to cause disease in chimpanzees or, to our knowledge, in humans. These data suggest that the risk of zoonotic viral disease from chimpanzee oral fluids in sanctuaries may be lower than commonly assumed. | |
dc.description.sponsorship | "This research was supported by National Institutes of Health awards R37AG049395 and R01AG049395 through the National Institute for Aging (https://nia.nih.gov) and the Office of Research on Women's Health (https://orwh.od.nih.gov) to MET, AGR, and TLG and a University of Wisconsin-Madison Global Health Institute (https://ghi.wisc.edu) Graduate Student Research Award to ED for research materials. ED was supported in the form of salary by the University of Wisconsin-Madison Comparative Biomedical Sciences Training Grant T32OD010423 from the National Institutes of Health Office of the Director (https://nih.gov). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript." | |
dc.identifier.citation | Dunay, Emily, Joshua Rukundo, Rebeca Atencia, et al. 'Viruses in Saliva from Sanctuary Chimpanzees (Pan Troglodytes) in Republic of Congo and Uganda', PloS One, vol. 18/no. 6, (2023), pp. e0288007-e0288007. | |
dc.identifier.issn | ISSN 1932-6203 | |
dc.identifier.issn | EISSN 1932-6203 | |
dc.identifier.uri | https://nru.uncst.go.ug/handle/123456789/9618 | |
dc.language.iso | en | |
dc.publisher | Public Library of Science | |
dc.title | Viruses in saliva from sanctuary chimpanzees (Pan troglodytes) in Republic of Congo and Uganda | |
dc.type | Article |