Physical Properties and Compactability of Various Blends of Fully Gelatinised and Pregelatinised Maize Starch

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dc.contributor.authorAngupale, Jimmy R.
dc.contributor.authorEngeu Ogwang, Patrick
dc.contributor.authorOkafor, Sylvester I.
dc.date.accessioned2021-12-15T09:31:49Z
dc.date.available2021-12-15T09:31:49Z
dc.date.issued2020
dc.description.abstractThe use of pregelatinised maize starch in direct compression as a sole binder produces tablets with relatively low tensile strength. Fully gelatinised maize starch possesses better binding properties but its use is limited in immediate release tablets. The aim of this work was to prepare a blend of fully gelatinised and pregelatinised maize starch possessing optimum tabletting properties. The pregelatinised starch was prepared by heating a 15 % slurry at 65 ℃ for 15 min followed by filtration and drying. The fully gelatinised starch was prepared by heating a 10 % slurry at 80 ℃ for 5min followed by precipitation with acetone, filtration and drying. The two samples were blended in 100:0, 25:75, 50:50, 75:25 and 0:100 proportions. Both local and BP starch samples were used and their blends compared for flow, packing characteristics and compactability. The disintegration time of the compacts was also determined. The results indicated that the BP starch blends exhibited better tabletting properties compared to the local starch. The proportion with 100 % fully gelatinised starch showed the best flow and compactability.en_US
dc.identifier.citationAngupale, J. R., Engeu, O. P., & Ignatius, O. S. (2020). Physical Properties and Compactability of Various Blends of Fully Gelatinised and Pregelatinised Maize Starch. Pharmaceutical and Biosciences Journal, 35-44.doi: 10.20510/ukjpb/8/i1/1581646140en_US
dc.identifier.issn25820540
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/558
dc.language.isoenen_US
dc.publisherPharmaceutical and Biosciences Journalen_US
dc.subjectPhysical Propertiesen_US
dc.subjectPregelatinised Maize Starchen_US
dc.subjectCompactabilityen_US
dc.titlePhysical Properties and Compactability of Various Blends of Fully Gelatinised and Pregelatinised Maize Starchen_US
dc.typeArticleen_US
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