Sensitivity And Specificity Of Hiv Rapid Tests Used For Research And Voluntary Counselling And Testing

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dc.contributor.authorAnzala, O.
dc.contributor.authorSanders, J.
dc.contributor.authorKamali, A.
dc.contributor.authorKatende, M.
dc.contributor.authorMutua, G. N.
dc.contributor.authorRuzagira, E.
dc.contributor.authorStevens G.
dc.contributor.authorSimek, M.
dc.contributor.authorPrice, M.
dc.date.accessioned2025-05-03T13:27:14Z
dc.date.available2025-05-03T13:27:14Z
dc.date.issued2009-02-04
dc.description.abstractBackground: HIV rapid tests (RT) are a quick and non-technically demanding means to perform HIV voluntary counselling and testing (VCT) but understanding their limitations is vital to delivering quality VCT. Objective: To determine the sensitivity and specificity of HIV rapid tests used for research and voluntary counselling and testing at four sites in East Africa. Design: Cross-sectional study. Setting: Masaka District, Uganda; a sugar plantation in Kakira, Uganda; Coastal Villages in the Kilifi District of Kenya; and the Urban slum of Kangemi located West of Nairobi, Kenya. Subjects: Six thousands two hundred and fifty five consenting volunteers were enrolled into the study, and 675 prevalent HIV infections were identified. Results: The RT sensitivity tended to be high for all assays at all sites (97.63-100%) with the exception of the Uni-Gold assay (90.24% in Kangemi, 96.58% in Kilifi). Twenty four RT results were recorded as ‘weak positives’, 22 (92%) of which were negative by ELISA. There was a high rate of RT false positives in Uganda (positive predictive values ranging from 45.70% to 86.62%). Conclusions: The sensitivity and specificity of the RT varied significantly across sites. The rate of RT misclassification in Uganda suggests that a multiple test algorithm may be preferable to a single test as screener for HIV VCT.
dc.identifier.citationAnzala, O., Sanders, J., Kamali, A., Katende, M., Mutua, G. N., Ruzagira, E., ... & Price, M. (2008). Sensitivity and specificity of HIV rapid tests used for research and voluntary counselling and testing. East African medical journal, 85(10), 500-504.
dc.identifier.doi10.4314/eamj.v85i10.9666
dc.identifier.issn0012-835X
dc.identifier.urihttps://www.ajol.info/index.php/eamj/article/view/9666/31077
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/11380
dc.language.isoen
dc.publisherAfrican Journals Online (AJOL)
dc.relation.ispartofEast African Medical Journal
dc.titleSensitivity And Specificity Of Hiv Rapid Tests Used For Research And Voluntary Counselling And Testing
dc.typejournal-article
oaire.citation.issue10
oaire.citation.volume85
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