Pharmacognostic, antiplasmodial and antipyretic evaluation of the aqueous extract of Vernonia amygdalina leaf

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dc.contributor.authorAdiukwu, Paul Chukwuemeka
dc.contributor.authorAgaba, Amon
dc.contributor.authorNambatya, Grace
dc.date.accessioned2022-03-09T11:57:43Z
dc.date.available2022-03-09T11:57:43Z
dc.date.issued2011
dc.description.abstractThe impeding safety challenges to the use of herbs have made qualitative and quantitative evaluation of herbal preparations a necessity. This study was aimed at evaluating the pharmacognostic and pharmacological properties of V. amygdalina leaf. Methods used include standard procedure for macroscopic and microscopic examinations; ash and extractive values determination; and quantitative evaluation of phytochemicals of the leaf aqueous extract. 4-day antiplasmodial suppression test using mice and antipyretic evaluation in rats induced pyrexia by i.p administration of 15% w/v Saccharomyces cerevisiae were carried out. Data showed presence of calcium oxalates and animocytic stomata. Extractive values suggest high aqueous soluble constituents. Saponin at 9.18% w/w } 0.19, among the phytochemicals evaluated was highest. Ash values: total ash 11.33% w/w } 0.15 and acid insoluble ash 1.89% w/w } 0.19, were obtained. Parasite suppression on day 4 and dose induced body temperature decrease, were significant (P . 0.05) for all the 3 dose levels of the extract used. Study agrees with folkloric use of the leaf extract in malaria fever but suggests substantial antipyretic property of the leaf.en_US
dc.identifier.citationAdiukwu, P. C., Amon, A., & Nambatya, G. (2011). Pharmacognostic, antiplasmodial and antipyretic evaluation of the aqueous extract of Vernonia amygdalina leaf. International Journal of Biological and Chemical Sciences, 5(2).https://doi.org/10.4314/ijbcs.v5i2.72134en_US
dc.identifier.issn1997-342X
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/2593
dc.language.isoenen_US
dc.publisherInternational Journal of Biological and Chemical Sciencesen_US
dc.subjectAsh and extractive values, parasite suppression, temperature decrease.en_US
dc.titlePharmacognostic, antiplasmodial and antipyretic evaluation of the aqueous extract of Vernonia amygdalina leafen_US
dc.typeArticleen_US
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