Bacterial vaginosis among women at high risk for HIV in Uganda: high rate of recurrent diagnosis despite treatment

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dc.contributor.authorFrancis, Suzanna C.
dc.contributor.authorLooker, Clare
dc.contributor.authorVandepitte, Judith
dc.contributor.authorBukenya, Justine
dc.contributor.authorMayanja, Yunia
dc.contributor.authorNakubulwa, Susan
dc.contributor.authorHughes, Peter
dc.contributor.authorHayes, Richard J.
dc.contributor.authorWeiss, Helen A.
dc.contributor.authorGrosskurth, Heiner
dc.date.accessioned2022-05-16T10:03:59Z
dc.date.available2022-05-16T10:03:59Z
dc.date.issued2016
dc.description.abstractBacterial vaginosis (BV) is associated with increased risk for sexually transmitted infections (STIs) and HIV acquisition. This study describes the epidemiology of BV in a cohort of women at high risk for STI/HIV in Uganda over 2 years of follow-up between 2008–2011. Methods 1027 sex workers or bar workers were enrolled and asked to attend 3-monthly follow-up visits. Factors associated with prevalent BV were analysed using multivariate random-effects logistic regression. The effect of treatment on subsequent episodes of BV was evaluated with survival analysis. Results Prevalences of BV and HIV at enrolment were 56% (573/1027) and 37% (382/1027), respectively. Overall, 905 (88%) women tested positive for BV at least once in the study, over a median of four visits. Younger age, a higher number of previous sexual partners and current alcohol use were independently associated with prevalent BV. BV was associated with STIs, including HIV. Hormonal contraception and condom use were protective against BV. Among 853 treated BV cases, 72% tested positive again within 3 months. There was no difference in time to subsequent BV diagnosis between treated and untreated women. Conclusions BV was highly prevalent and persistent in this cohort despite treatment. More effective treatment strategies are urgently needed.en_US
dc.identifier.citationFrancis, SC, Looker, C., Vandepitte, J., Bukenya, J., Mayanja, Y., Nakubulwa, S., ... & Grosskurth, H. (2016). Bacterial vaginosis among women at high risk for HIV in Uganda: high rate of recurrent diagnosis despite treatment. Sexually transmitted infections , 92 (2), 142-148. http://dx.doi.org/10.1136/ sextrans-2015-052160en_US
dc.identifier.urihttp://dx.doi.org/10.1136/ sextrans-2015-052160
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/3239
dc.language.isoenen_US
dc.publisherSexually transmitted infectionsen_US
dc.subjectBacterial vaginosisen_US
dc.subjectWomenen_US
dc.subjectHIVen_US
dc.subjectUgandaen_US
dc.titleBacterial vaginosis among women at high risk for HIV in Uganda: high rate of recurrent diagnosis despite treatmenten_US
dc.typeArticleen_US
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