Incidence of acute rheumatic fever in northern and western Uganda: a prospective, population-based study

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dc.contributor.authorOkello, Emmy
dc.contributor.authorNdagire, Emma
dc.contributor.authorMuhamed, Babu
dc.contributor.authorSarnacki, Rachel
dc.contributor.authorNakitto, M.G.
dc.contributor.authorKansiime, Rosemary
dc.contributor.authorLongenecker, Chris T.
dc.contributor.authorLwabi, Peter
dc.contributor.authorAgaba, Collins
dc.contributor.authorOmara, Isaac Otim
dc.contributor.authorOyella, Linda Mary
dc.contributor.authorRwebembera, Joselyn
dc.contributor.authorWatkins, David
dc.contributor.authorCarapetis, Jonathan R.
dc.date.accessioned2023-04-03T15:31:49Z
dc.date.available2023-04-03T15:31:49Z
dc.date.issued2021
dc.description.abstractAcute rheumatic fever is infrequently diagnosed in sub-Saharan African countries despite the high prevalence of rheumatic heart disease. We aimed to determine the incidence of acute rheumatic fever in northern and western Uganda. For our prospective epidemiological study, we established acute rheumatic fever clinics at two regional hospitals in the north (Lira district) and west (Mbarara district) of Uganda and instituted a comprehensive acute rheumatic fever health messaging campaign. Communities and health-care workers were encouraged to refer children aged 3–17 years, with suspected acute rheumatic fever, for a definitive diagnosis using the Jones Criteria. Children were referred if they presented with any of the following: (1) history of fever within the past 48 h in combination with any joint complaint, (2) suspicion of acute rheumatic carditis, or (3) suspicion of chorea. We excluded children with a confirmed alternative diagnosis. We estimated incidence rates among children aged 5–14 years and characterised clinical features of definite and possible acute rheumatic fever cases. Data were collected between Jan 17, 2018, and Dec 30, 2018, in Lira district and between June 5, 2019, and Feb 28, 2020, in Mbarara district. Of 1075 children referred for evaluation, 410 (38%) met the inclusion criteria; of these, 90 (22%) had definite acute rheumatic fever, 82 (20·0%) had possible acute rheumatic fever, and 24 (6%) had rheumatic heart disease without evidence of acute rheumatic fever. Additionally, 108 (26%) children had confirmed alternative diagnoses and 106 (26%) had an unknown alternative diagnosis. We estimated the incidence of definite acute rheumatic fever among children aged 5–14 years as 25 cases (95% CI 13·7–30·3) per 100 000 person-years in Lira district (north) and 13 cases (7·1–21·0) per 100 000 person-years in Mbarara district (west).en_US
dc.identifier.citationOkello, E., Ndagire, E., Muhamed, B., Sarnacki, R., Murali, M., Pulle, J., ... & Beaton, A. (2021). Incidence of acute rheumatic fever in northern and western Uganda: a prospective, population-based study. The Lancet Global Health, 9(10), e1423-e1430.https://doi.org/10.1016/S2214-109X(21)00288-6en_US
dc.identifier.issn2214-109X
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/8392
dc.language.isoenen_US
dc.publisherThe Lancet Global Healthen_US
dc.subjectAcute rheumatic feveren_US
dc.subjectPopulationen_US
dc.titleIncidence of acute rheumatic fever in northern and western Uganda: a prospective, population-based studyen_US
dc.typeArticleen_US
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