Survival of Infants Born to HIV-Positive Mothers, by Feeding Modality, in Rakai, Uganda

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dc.contributor.authorKagaayi, Joseph
dc.contributor.authorGray, Ronald H.
dc.contributor.authorBrahmbhatt, Heena
dc.contributor.authorKigozi, Godfrey
dc.contributor.authorNalugoda, Fred
dc.contributor.authorWabwire-Mangen, Fred
dc.contributor.authorSerwadda, David
dc.contributor.authorSewankambo, Nelson
dc.contributor.authorDdungu, Veronica
dc.contributor.authorSsebagala, Darix
dc.contributor.authorSekasanvu, Joseph
dc.contributor.authorKigozi, Grace
dc.contributor.authorMakumbi, Fredrick
dc.contributor.authorKiwanuka, Noah
dc.contributor.authorLutalo, Tom
dc.contributor.authorReynolds, Steven J.
dc.contributor.authorWawer, Maria J.
dc.date.accessioned2022-01-24T23:37:51Z
dc.date.available2022-01-24T23:37:51Z
dc.date.issued2008
dc.description.abstractData comparing survival of formula-fed to breast-fed infants in programmatic settings are limited. We compared mortality and HIV-free of breast and formula-fed infants born to HIV-positive mothers in a program in rural, Rakai District Uganda. One hundred eighty two infants born to HIV-positive mothers were followed at one, six and twelve months postpartum. Mothers were given infant-feeding counseling and allowed to make informed choices as to whether to formula-feed or breast-feed. Eligible mothers and infants received antiretroviral therapy (ART) if indicated. Mothers and their newborns received prophylaxis for prevention of mother-to-child HIV transmission (pMTCT) if they were not receiving ART. Infant HIV infection was detected by PCR (Roche Amplicor 1.5) during the follow-up visits. Kaplan Meier time-to-event methods were used to compare mortality and HIV-free survival. The adjusted hazard ratio (Adjusted HR) of infant HIV-free survival was estimated by Cox regression. Seventy-five infants (41%) were formula-fed while 107 (59%) were breast-fed. Exclusive breast-feeding was practiced by only 25% of breast-feeding women at one month postpartum. The cumulative 12-month probability of infant mortality was 18% (95% CI = 11%–29%) among the formula-fed compared to 3% (95% CI = 1%–9%) among the breast-fed infants (unadjusted hazard ratio (HR) = 6.1(95% CI = 1.7–21.4, P-value,0.01). There were no statistically significant differentials in HIV-free survival by feeding choice (86% in the formula-fed compared to 96% in breast-fed group (Adjusted RH = 2.8[95%CI = 0.67–11.7, P-value = 0.16]en_US
dc.identifier.citationKagaayi J, Gray RH, Brahmbhatt H, Kigozi G, Nalugoda F, et al. (2008) Survival of Infants Born to HIV-Positive Mothers, by Feeding Modality, in Rakai, Uganda. PLoS ONE 3(12): e3877. doi:10.1371/journal.pone.0003877en_US
dc.identifier.other10.1371/journal.pone.0003877
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1546
dc.language.isoenen_US
dc.publisherPLoS ONEen_US
dc.subjectInfants Bornen_US
dc.subjectHIV-Positive Mothersen_US
dc.subjectFeeding Modalityen_US
dc.subjectUgandaen_US
dc.titleSurvival of Infants Born to HIV-Positive Mothers, by Feeding Modality, in Rakai, Ugandaen_US
dc.typeArticleen_US
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