Differences in body circumference, skin fold thickness and lipid profile measurements among HIV-infected children on and not on stavudine-based therapy in Uganda and Zambia in the CHAPAS-3 clinical trial

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dc.contributor.authorMusiime, Victor
dc.contributor.authorCook, Adrian.
dc.contributor.authorKayiwa, Joshua
dc.contributor.authorZangata, Dorothy
dc.contributor.authorGibb, Diana M.
dc.contributor.authorKityo, Cissy
dc.contributor.authorKekitiinwa, Adeodata
dc.contributor.authorMulenga, Veronica
dc.contributor.authorNansubuga, Carol
dc.contributor.authorArach, Beatrice
dc.contributor.authorKenny, Julia
dc.contributor.authorWavamunno, Priscilla
dc.contributor.authorKabamba, Desiree
dc.contributor.authorAsiimwe, Alice R.
dc.contributor.authorAbongomera, George
dc.date.accessioned2021-12-10T11:44:24Z
dc.date.available2021-12-10T11:44:24Z
dc.date.issued2013
dc.description.abstractLipodystrophy is a major side effect of antiretroviral therapy (ART) especially in adults, and although there have been some reports among HIV-infected children [1,2], paediatric data are limited Stavudine (d4T) has particularly been associated with lipodystrophy among HIVinfected adults owing to intracellular accumulation of the drug and its metabolites In HIV-infected children, d4T clearance is enhanced, potentially protecting them from these effects [3]. In addition, the relative d4T dose in paediatric fixed dosecombination “baby” tablets is lower than used in adults, and is also lower compared to the 4mg/kg licensed dose for children [4] Features of lipodystrophy have been observed to reverse when children have been switched from d4T-containing regimens [5]; however, clinical lipodystrophy ismore difficult to diagnose in growing children than in adults We compared body circumferences, skin-fold thickness (SFT) and lipid levels, as objective measures of lipodystrophy, among HIV-infected ART naïve vs experienced children at enrolment into the CHAPAS-3 trial, and in HIV-uninfecteden_US
dc.identifier.citationMusiime, V., Cook, A., Kayiwa, J., Zangata, D., Nansubuga, C., Arach, B., ... & Gibb, D. M. Differences in body circumference, skin fold thickness and lipid profile measurements among HIV-infected children on and not on stavudine-based therapy in Uganda and Zambia in the CHAPAS-3 clinical trial.en_US
dc.identifier.urihttps://www.academia.edu/download/44435724/Differences_in_body_circumferences_skin-20160405-4476-199jeqh.pdf
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/248
dc.language.isoenen_US
dc.publisherJoint Clinical Research Centreen_US
dc.subjectHIVen_US
dc.subjectinfected childrenen_US
dc.subjectskin fold thicknessen_US
dc.subjectlipid profileen_US
dc.subjectCHAPAS-3 clinical trialen_US
dc.titleDifferences in body circumference, skin fold thickness and lipid profile measurements among HIV-infected children on and not on stavudine-based therapy in Uganda and Zambia in the CHAPAS-3 clinical trialen_US
dc.typeArticleen_US
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