Synergistic anti-inflammatory activities of a new flavone and other flavonoids from Tephrosia hildebrandtii vatke

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dc.contributor.authorOwor, Richard Oriko
dc.contributor.authorBedane, Kibrom Gebreheiwot
dc.contributor.authorOpenda, Yolande Ikala
dc.contributor.authorZ€uhlke, Sebastian
dc.contributor.authorDerese, Solomon
dc.contributor.authorOng’amo, George
dc.contributor.authorNdakala, Albert
dc.contributor.authorSpiteller, Michael
dc.date.accessioned2022-06-01T20:09:04Z
dc.date.available2022-06-01T20:09:04Z
dc.date.issued2021
dc.description.abstractA new flavone, named hildeflavone (1) along with 7 other known flavonoids were isolated from the aerial parts of Tephrosia hildebrandtii Vatke. Their characterisation was based on NMR and MS data analysis. The anti-inflammatory properties of the crude extract, isolated compounds and combination of the compounds were investigated in lipopolysaccharide (LPS)-stimulated peripheral blood mononuclear cells (PBMCs). Treatment of the LPS-stimulated PBMCs with the isolated flavonoids at a concentration of 100 µM significantly reduced the production of interleukins (IL-1β, IL-2 and IL-6), interferon-gamma (IFN-γ), granulocyte macrophage-colony stimulating factor (GM-CSF) and tumour necrosis factor-alpha (TNF-α). It was also found that the combination of a flavone and flavanones exhibited remarkable synergistic anti-inflammatory effects on the production of the cytokines.en_US
dc.identifier.citationOwor, R. O., Bedane, K. G., Openda, Y. I., Zühlke, S., Derese, S., Ong’amo, G., ... & Spiteller, M. (2021). Synergistic anti-inflammatory activities of a new flavone and other flavonoids from Tephrosia hildebrandtii vatke. Natural Product Research, 35(22), 4486-4493.https://doi.org/10.1080/14786419.2020.1736065en_US
dc.identifier.issn1478-6419
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/3651
dc.language.isoenen_US
dc.publisherNatural Product Researchen_US
dc.subjectFabaceae; Tephrosia hildebrandtii; flavonoid; anti-inflammatory; hildeflavone; cytokine; synergyen_US
dc.titleSynergistic anti-inflammatory activities of a new flavone and other flavonoids from Tephrosia hildebrandtii vatkeen_US
dc.typeArticleen_US
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