Human Immunodeficiency Virus Type 1 Infection Is Associated with Increased NK Cell Polyfunctionality and Higher Levels of KIR3DL1+ NK Cells in Ugandans Carrying the HLA-B Bw4 Motif
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Date
2000
Journal Title
Journal ISSN
Volume Title
Publisher
The Journal of infectious diseases
Abstract
Natural killer (NK) cells are important innate effector cells controlled by an array of activating and
inhibitory receptors. Some alleles of the inhibitory killer-cell immunoglobulin-like receptor KIR3DL1 in
combination with its HLA class I ligand Bw4 have been genetically associated with slower HIV-1 disease
progression. Here, we observed that the presence of HLA-B Bw4 was associated with elevated frequencies of
KIR3DL1 CD56dim NK cells in chronically HIV-1-infected individuals from the rural district of Kayunga,
Uganda. In contrast, levels of KIR2DL1 CD56dim NK cells were decreased, and levels of KIR2DL3 CD56dim
NK cells were unchanged in infected subjects carrying their respective HLA-C ligands. Furthermore, the size
of the KIR3DL1 NK cell subset correlated directly with viral load, and this effect occurred only in HLA-B
Bw4 patients, suggesting that these cells expand in response to viral replication but may have relatively poor
antiviral capacity. In contrast, no association with viral load was present for KIR2DL1 and KIR2DL3 NK
cells. Interestingly, chronic HIV-1 infection was associated with an increased polyfunctional response in the
NK cell compartment, and, upon further investigation, KIR3DL1 CD56dim NK cells exhibited a significantly
increased functional response in the patients carrying HLA-B Bw4. These results indicate that chronic HIV-1
infection is associated with increased NK cell polyfunctionality and elevated levels of KIR3DL1 NK cells in
Ugandans carrying the HLA-B Bw4 motif.
Description
Keywords
Human Immunodeficiency Virus Type 1 Infection, NK Cell Polyfunctionality, KIR3DL1+ NK Cells, Ugandans, HLA-B Bw4 Motif
Citation
Olsson, J., Poles, M., Spetz, A. L., Elliott, J., Hultin, L., Giorgi, J., ... & Anton, P. (2000). Human immunodeficiency virus type 1 infection is associated with significant mucosal inflammation characterized by increased expression of CCR5, CXCR4, and β-chemokines. The Journal of infectious diseases, 182(6), 1625-1635. doi:10.1128/JVI.00111-11