Longitudinal seroprevalence of Crimean-Congo hemorrhagic fever virus in Southern Uganda

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dc.contributor.authorMihalakakos, Evan A.;
dc.contributor.authorSsempijja, Victor;
dc.contributor.authorRibeiro, Ruy M. ;
dc.contributor.authorMolina-Paris, Carmen;
dc.contributor.authorKatushabe, Gerald;
dc.contributor.authorNalwadda, Josephine;
dc.contributor.authorOmooja, Jonah;
dc.contributor.authorByarugaba, Denis K.;
dc.contributor.authorRosenke, Kyle;
dc.contributor.authorReynolds, Steven J.;
dc.contributor.authorGrabowski, Mary K.;
dc.contributor.authorGaliwango, Ronald M.;
dc.contributor.authorSsekubugu, Robert;
dc.contributor.authorFeldmann, Heinz;
dc.contributor.authorHawman, David W.
dc.date.accessioned2025-05-20T14:01:30Z
dc.date.available2025-05-20T14:01:30Z
dc.date.issued2025-03-03
dc.description.abstractAbstract Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne disease endemic to many regions of Africa, the Middle East, Southeast Asia and the Balkans. Caused by the CCHF virus (CCHFV), CCHF has been a recognized cause of illness in Uganda since the 1950s and recently, more intensive surveillance suggests CCHFV is widely endemic within the country. Most surveillance has been focused on the Ugandan cattle corridor due to the risk of CCHFV exposure associated with livestock practices. Here we evaluated the seroprevalence of CCHFV in several Southern Ugandan communities outside the cattle corridor combined with longitudinal sample sets to measure the immune response to CCHFV for up to a decade. Interestingly, across three community types, agrarian, trading and fishing, we detected CCHFV seroprevalence in all three but found the highest seroprevalence in fishing communities. We also measured consistent CCHFV-specific antibody responses for up to a decade. Our findings support the conclusion that CCHFV is widely endemic in Uganda and highlight that additional communities may be at risk for CCHFV exposure.Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne disease endemic to many regions of Africa, the Middle East, Southeast Asia and the Balkans. Caused by the CCHF virus (CCHFV), CCHF has been a recognized cause of illness in Uganda since the 1950s and recently, more intensive surveillance suggests CCHFV is widely endemic within the country. Most surveillance has been focused on the Ugandan cattle corridor due to the risk of CCHFV exposure associated with livestock practices. Here we evaluated the seroprevalence of CCHFV in several Southern Ugandan communities outside the cattle corridor combined with longitudinal sample sets to measure the immune response to CCHFV for up to a decade. Interestingly, across three community types, agrarian, trading and fishing, we detected CCHFV seroprevalence in all three but found the highest seroprevalence in fishing communities. We also measured consistent CCHFV-specific antibody responses for up to a decade. Our findings support the conclusion that CCHFV is widely endemic in Uganda and highlight that additional communities may be at risk for CCHFV exposure. MEDLINE - Academic
dc.description.sponsorshipThis study was supported in part by the National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) (U01AI075115, U01AI100031, ZIAAI001040, R01AI114438, K25AI114461, R01AI123002, K01AI125086, R01AI143333, R21AI145682, R01AI155080, AI167048-01), NIH National Institute of Child Health and Development (R01HD070769, R01HD091003), NIH National Heart, Lung, and Blood Institute (R01HL152813), National Institute of Mental Health (R01MH099733, F31MH095649, R01MH105313, R01MH107275, R01MH115799), National Institute on Alcohol Abuse and Alcoholism (K01AA024068), Bill and Melinda Gates Foundation (OPP1084362), the Johns Hop kins University Center for AIDS Research (2P30AI094189), the U.S. President’s Emergency Plan for AIDS Relief through the Centers for Disease Control and Prevention (NU2GGH00081), and supported in part by the Division of Intramural Research, NIAID, NIH
dc.identifier.citationMihalakakos, Evan A., Victor Ssempijja, Ruy M. Ribeiro, et al. 'Longitudinal Seroprevalence of Crimean-Congo Hemorrhagic Fever Virus in Southern Uganda', Emerging Microbes & Infections, vol. 14/no. 1, (2025), pp. 2465315.
dc.identifier.issnISSN 2222-1751
dc.identifier.issnEISSN 2222-1751
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/11728
dc.language.isoen
dc.publisherNature Publishing Group
dc.titleLongitudinal seroprevalence of Crimean-Congo hemorrhagic fever virus in Southern Uganda
dc.typeArticle
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