Grain Amaranth Is Associated with Improved Hepatic and Renal Calcium Metabolism in Type 2 Diabetes Mellitus of Male Wistar Rats

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dc.contributor.authorKasozi, Keneth Iceland
dc.contributor.authorNamubiru, Sarah
dc.contributor.authorSafiriyu, Abass Alao
dc.contributor.authorNinsiima, Herbert Izo
dc.contributor.authorNakimbugwe, Dorothy
dc.contributor.authorNamayanja, Monica
dc.contributor.authorValladares, Miriela Betancourt
dc.date.accessioned2022-09-08T19:24:44Z
dc.date.available2022-09-08T19:24:44Z
dc.date.issued2018
dc.description.abstractDysregulation of calcium signaling is a hallmark of diabetes mellitus (DM) and grain amaranth (AG) has antidiabetic properties. Information on the mechanism of action of AG on blood, renal, and hepatic tissues is sparse, although it continues to be an important alternative medicinal plant in several developing countries. The objective of the study was to determine key changes in calcium levels and s100a1 protein levels and antioxidant and histopathologic changes in blood, renal, and hepatic tissues of male diabetic Wistar rats. Materials and Methods. This was an experimental study in which 30 male Wistar rats were kept for 5 weeks (6 groups, N =5). Groups 1-IV had T2DM induced using Nicotinamide and Streptozotocin: Group I, Mixtard®; group II, positive control; group III, 25% AG; group IV, 50% AG. Furthermore, group V consisted of normal rats given 50% GA and group VI was negative control. Blood, renal, and hepatic tissues were collected and analyzed for calcium, s100a1 protein levels, and antioxidant and histopathological changes. Results and Discussion. In blood, renal, and hepatic tissue, calcium and s100a1 levels were low during T2DM and these increased following AG supplementation. This was important for improved metabolic processes, thus leading to the low malondialdehyde (MDA) and glutathione peroxidase (GPx) activity in the tissues. Efficient antioxidant status was important for improved calcium signaling mechanisms, thus leading to improved tissue function and protection demonstrating the importance of AG as an alternative medicinal source through the calcium signaling pathway. Conclusion. Grain amaranth exerts its antidiabetic properties through improved calcium homeostasis in blood, kidney, and liver.en_US
dc.identifier.citationKasozi, K. I., Namubiru, S., Safiriyu, A. A., Ninsiima, H. I., Nakimbugwe, D., Namayanja, M., & Valladares, M. B. (2018). Grain Amaranth is associated with improved hepatic and renal calcium metabolism in type 2 diabetes mellitus of male Wistar rats. Evidence-Based Complementary and Alternative Medicine, 2018.https://doi.org/10.1155/2018/4098942en_US
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/4639
dc.language.isoenen_US
dc.publisherEvidence-Based Complementary and Alternative Medicineen_US
dc.titleGrain Amaranth Is Associated with Improved Hepatic and Renal Calcium Metabolism in Type 2 Diabetes Mellitus of Male Wistar Ratsen_US
dc.typeArticleen_US
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