Abbreviated HIV counselling and testing and enhanced referral to care in Uganda: a factorial randomised controlled trial

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dc.contributor.authorWanyenze, Rhoda K.
dc.contributor.authorKamya, Moses R.
dc.contributor.authorFatch, Robin
dc.contributor.authorMayanja-Kizza, Harriet
dc.contributor.authorBaveewo, Steven
dc.contributor.authorSzekeres, Gregory
dc.contributor.authorBangsberg, David
dc.contributor.authorCoates, Thomas
dc.contributor.authorHahn, Judith A.
dc.date.accessioned2022-02-11T09:54:59Z
dc.date.available2022-02-11T09:54:59Z
dc.date.issued2013
dc.description.abstractHIV counselling and testing and linkage to care are crucial for successful HIV prevention and treatment. Abbreviated counselling could save time; however, its eff ect on HIV risk is uncertain and methods to improve linkage to care have not been studied. We did this factorial randomised controlled study at Mulago Hospital, Uganda. Participants were randomly assigned to abbreviated or traditional HIV counselling and testing; HIV-infected patients were randomly assigned to enhanced linkage to care or standard linkage to care. All study personnel except counsellors and the data offi cer were masked to study group assignment. Participants had structured interviews, given once every 3 months. We compared sexual risk behaviour by counselling strategy with a 6·5% non-inferiority margin. We used Cox proportional hazards analyses to compare HIV outcomes by linkage to care over 1 year and tested for interaction by sex. This trial is registered with ClinicalTrials.gov (NCT00648232). We enrolled 3415 participants; 1707 assigned to abbreviated counselling versus 1708 assigned to traditional. Unprotected sex with an HIV discordant or status unknown partner was similar in each group (232/823 [27·9%] vs 251/890 [28·2%], diff erence –0·3%, one-sided 95% CI 3·2). Loss to follow-up was lower for traditional counselling than for abbreviated counselling (adjusted hazard ratio [HR] 0·61, 95% CI 0·44–0·83). 1003 HIV-positive participants were assigned to enhanced linkage (n=504) or standard linkage to care (n=499). Linkage to care did not have a signifi cant eff ect on mortality or receipt of co-trimoxazole. Time to treatment in men with CD4 cell counts of 250 cells per μL or fewer was lower for enhanced linkage versus standard linkage (adjusted HR 0·60, 95% CI 0·41–0·87) and time to HIV care was decreased among women (0·80, 0·66–0·96).en_US
dc.identifier.citationWanyenze, R. K., Kamya, M. R., Fatch, R., Mayanja-Kizza, H., Baveewo, S., Szekeres, G., ... & Hahn, J. A. (2013). Abbreviated HIV counselling and testing and enhanced referral to care in Uganda: a factorial randomised controlled trial. The Lancet Global Health, 1(3), e137-e145.en_US
dc.identifier.uriWanyenze, R. K., Kamya, M. R., Fatch, R., Mayanja-Kizza, H., Baveewo, S., Szekeres, G., ... & Hahn, J. A. (2013). Abbreviated HIV counselling and testing and enhanced referral to care in Uganda: a factorial randomised controlled trial. The Lancet Global Health, 1(3), e137-e145.
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/2062
dc.language.isoenen_US
dc.publisherThe Lancet Global Healthen_US
dc.subjectHIV counsellingen_US
dc.subjectHIV preventionen_US
dc.subjectAbbreviated counsellingen_US
dc.titleAbbreviated HIV counselling and testing and enhanced referral to care in Uganda: a factorial randomised controlled trialen_US
dc.typeArticleen_US
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