Prevalence, clinical characteristics and treatment outcomes of HIV and SARS-CoV-2 co-infection: a systematic review and meta-analysis

Simple item page
dc.contributor.authorBaruch Baluku, Joseph
dc.contributor.authorOlum, Ronald
dc.contributor.authorAgolor, Curthbert
dc.contributor.authorNakakande, Josephine
dc.contributor.authorRussell, Laura
dc.contributor.authorBongomin, Felix
dc.contributor.authorNakawesi, Jane
dc.date.accessioned2023-01-24T11:14:49Z
dc.date.available2023-01-24T11:14:49Z
dc.date.issued2022
dc.description.abstractTo determine the prevalence, clinical characteristics and outcomes of HIV and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) co-infection. Methods: We searched Medline, Embase, Cochrane and Web of Science databases and grey literature for studies reporting epidemiological and clinical data of patients with HIV and SARS-CoV-2 co-infection. Eligible studies were all observational or interventional studies and commentaries in English language that reported patient data on HIV/SARS-CoV-2 co-infection. We used random effect meta-analysis to determine the pooled prevalence and mortality. Results: Of the 17 eligible studies, there were 3 retrospective cohorts, 1 survey, 5 case series, 7 case reports and 1 commentary that reported on a total of 146 HIV infected individuals. The pooled prevalence of HIV among individuals with SARS-CoV-2 infection was 1.0% (95% CI: 0.0 – 3.0, I2 = 79.3%, p=0.01), whereas the prevalence of SARS-CoV-2 among HIV patients was 0.68% (95% CI: 0.34 – 1.34).There were 110 (83.8%) HIV/ SARS-CoV-2 co-infected males, and the age (range) of the co-infected was 30 – 60 years. A total of 129 (97.0%) were anti-retroviral therapy experienced, and 113 (85.6%) had a suppressed HIV viral load. The CD4 count (range) was 298 – 670 cells/mm3 (n = 107). The commonest symptoms were fever (73.5%, n=75) and cough (57.8%, n = 59). Sixty-two (65.3%) patients had at least one other comorbid condition, of which hypertension (26.4%, n = 38) was the commonest. Chest radiological imaging abnormalities were found in 46 (54.1%) cases. Twenty-eight cases (56.0%) were reported as mild. Recovery occurred in 120 (88.9%) cases, and the pooled mortality was 9% (95% CI: 3.0 – 15.0, I2 = 25.6%, p =0.24). Conclusion: The prevalence of HIV/SARS-CoV-2 co-infection was low. The clinical characteristics and outcomes of HIV/SARS-CoV-2 co-infection are comparable to those reported among HIV negative SARS-CoV-2 cases. It is made available under a CC-BY-NC-ND 4.0 International license . (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. medRxiv preprint doi: https://doi.org/10.1101/2020.05.31.20118497; this version posted June 3, 2020. The copyright holder for this preprinten_US
dc.identifier.citationBaluku, J. B., Olum, R., Agolor, C., Nakakande, J., Russell, L., Bongomin, F., & Nakawesi, J. (2020). Prevalence, clinical characteristics and treatment outcomes of HIV and SARS-CoV-2 co-infection: a systematic review and meta-analysis. medRxiv. https://doi.org/10.1101/2020.05.31.20118497en_US
dc.identifier.urihttps://doi.org/10.1101/2020.05.31.20118497
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/7149
dc.language.isoenen_US
dc.publishermedRxiven_US
dc.subjectHIVen_US
dc.subjectCOVID -19en_US
dc.subjectClinical manifestationsen_US
dc.subjectOutcomesen_US
dc.subjectCorona virusen_US
dc.titlePrevalence, clinical characteristics and treatment outcomes of HIV and SARS-CoV-2 co-infection: a systematic review and meta-analysisen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Prevalence, clinical characteristics and treatment outcomes of HIV and SARS-CoV-2.pdf
Size:
584.84 KB
Format:
Adobe Portable Document Format
Description:
Article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Medical and Health Sciences