Cerebral Malaria in Children Is Associated With Long-term Cognitive Impairment

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dc.contributor.authorJohn, Chandy C.
dc.contributor.authorBangirana, Paul
dc.contributor.authorByarugaba, Justus
dc.contributor.authorOpoka, Robert O.
dc.contributor.authorIdro, Richard
dc.contributor.authorJurek, Anne M.
dc.contributor.authorWu, Baolin
dc.contributor.authorBoivin, Michael J.
dc.date.accessioned2022-02-08T19:51:24Z
dc.date.available2022-02-08T19:51:24Z
dc.date.issued2008
dc.description.abstractCerebral malaria affects >785000 African children every year. We previously documented an increased frequency of cognitive impairment in children with cerebral malaria 6 months after their initial malaria episode. This study was conducted to determine the long-term effects of cerebral malaria on the cognitive function of these children.Children who were 5 to 12 years of age and presented to Mulago Hospital, Kampala, Uganda, with cerebral malaria (n = 44) or uncomplicated malaria (n = 54), along with healthy, asymptomatic community children (n = 89), were enrolled in a prospective cohort study of cognition. Cognitive testing was performed at enrollment and 2 years later. The primary outcome was presence of a deficit in ≥1 of 3 cognitive areas tested.At 2-year follow-up testing, 26.3% of children with cerebral malaria and 12.5% with uncomplicated malaria had cognitive deficits in ≥1 area, as compared with 7.6% of community children. Deficits in children with cerebral malaria were primarily in the area of attention (cerebral malaria, 18.4%, vs community children, 2.5%). After adjustment for age, gender, nutrition, home environment, and school level, children with cerebral malaria had a 3.67-fold increased risk for a cognitive deficit compared with community children. Cognitive impairment at 2-year follow-up was associated with hyporeflexia on admission and neurologic deficits 3 months after discharge.Cerebral malaria is associated with long-term cognitive impairments in 1 of 4 child survivors. Future studies should investigate the mechanisms involved so as to develop interventions aimed at prevention and rehabilitation.en_US
dc.identifier.citationJohn, C. C., Bangirana, P., Byarugaba, J., Opoka, R. O., Idro, R., Jurek, A. M., ... & Boivin, M. J. (2008). Cerebral malaria in children is associated with long-term cognitive impairment. Pediatrics, 122(1), e92-e99.https://doi.org/10.1542/peds.2007-3709en_US
dc.identifier.issn1098-4275
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/2010
dc.language.isoenen_US
dc.publisherPediatricsen_US
dc.subjectcerebral malaria; cognitive; deficit; impairment; P falciparumen_US
dc.titleCerebral Malaria in Children Is Associated With Long-term Cognitive Impairmenten_US
dc.typeArticleen_US
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