Innate and Adaptive Immune Responses during Acute M. tuberculosis Infection in Adult Household Contacts in Kampala, Uganda

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dc.contributor.authorMahan, C. Scott
dc.contributor.authorZalwango, Sarah
dc.contributor.authorThiel, Bonnie A.
dc.contributor.authorMalone, LaShaunda L.
dc.contributor.authorChervenak, Keith A.
dc.contributor.authorBaseke, Joy
dc.contributor.authorDobbs, Dennis
dc.contributor.authorStein, Catherine M.
dc.contributor.authorMayanja, Harriet
dc.contributor.authorJoloba, Moses
dc.contributor.authorWhalen, Christopher C.
dc.contributor.authorBoom, W. Henry
dc.date.accessioned2021-12-10T11:48:35Z
dc.date.available2021-12-10T11:48:35Z
dc.date.issued2011
dc.description.abstractContacts of active pulmonary tuberculosis (TB) patients are at risk for Mycobacterium tuberculosis (MTB) infection. Because most infections are controlled, studies during MTB infection provide insight into protective immunity. We compared immune responses of adult household contacts that did and did not convert the tuberculin skin test (TST). Innate and adaptive immune responses were measured by whole blood assay. Responses of TST converters (TSTC) were compared with persistently TST negative contacts (PTST–) and contacts who were TST+ at baseline (TST+). TLR-2, TLR-4, and IFN-gR responses to IFN-g did not differ between the groups, nor did gd T cell responses. T cell responses to MTB antigens differed markedly among TSTC, PTST–, and TST+ contacts. Thus, no differences in innate responses were found among the three household contact groups. However, adaptive T cell responses to MTB antigens did differ before and during MTB infection among PTST–, TSTC, and TST+ contacts.en_US
dc.identifier.citationMahan, C. S., Zalwango, S., Thiel, B. A., Malone, L. L., Chervenak, K. A., Baseke, J., ... & Boom, W. H. (2012). Innate and adaptive immune responses during acute M. tuberculosis infection in adult household contacts in Kampala, Uganda. The American journal of tropical medicine and hygiene, 86(4), 690.doi:10.4269/ajtmh.2012.11-0553en_US
dc.identifier.other10.4269/ajtmh.2012.11-0553
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/249
dc.language.isoenen_US
dc.publisherThe American journal of tropical medicine and hygieneen_US
dc.subjectImmune Responsesen_US
dc.subjectTuberculosis Infectionen_US
dc.subjectHousehold Contactsen_US
dc.titleInnate and Adaptive Immune Responses during Acute M. tuberculosis Infection in Adult Household Contacts in Kampala, Ugandaen_US
dc.typeArticleen_US
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