Therapeutic Lumbar Punctures in HIV-associated Cryptococcal Meningitis: should opening pressure direct management?

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dc.contributor.authorKagimu, Enock
dc.contributor.authorEngen, Nicole
dc.contributor.authorSsebambulidde, Kenneth
dc.contributor.authorKasibante, John
dc.contributor.authorKiiza, Tadeo K
dc.contributor.authorMpoza, Edward
dc.contributor.authorL., Lillian Tugume
dc.contributor.authorNuwagira, Edwin
dc.contributor.authorNsangi, Laura
dc.contributor.authorMeya, David B.
dc.contributor.authorRhein, Joshua
dc.contributor.authorAbassi, Mahsa
dc.contributor.authorMusubire, Abdu K.
dc.date.accessioned2023-07-03T16:07:10Z
dc.date.available2023-07-03T16:07:10Z
dc.date.issued2022
dc.description.abstractIncreased intracranial pressure (ICP) frequently complicates cryptococcal meningitis. Therapeutic lumbar punctures (LPs) have acute survival benefits in the first week, and we sought to understand the longer-term survival impact of therapeutic LPs. We prospectively enrolled HIV-seropositive adults with cryptococcal meningitis from 2013 to 2017 in Uganda. CSF opening pressure was measured at diagnosis. Therapeutic LPs were scheduled on days 3, 7, 10, 14, and performed additionally as clinically indicated. We assessed the association between clinical characteristics, CSF parameters, and 14- and 30-day mortality by baseline ICP. We also assessed 30-day mortality by number of follow-up therapeutic LPs performed within 7 days.en_US
dc.identifier.citationKagimu, E., Engen, N., Ssebambulidde, K., Kasibante, J., Kiiza, T. K., Mpoza, E., ... & Musubire, A. K. (2022). Therapeutic lumbar punctures in HIV-associated cryptococcal meningitis: should opening 3 pressure direct management. In Open Forum Infectious Diseases.en_US
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/9031
dc.language.isoenen_US
dc.publisherIn Open Forum Infectious Diseases.en_US
dc.subjectBaseline Opening Pressureen_US
dc.subjectMortalityen_US
dc.subjectTherapeutic Lumbar Punctureen_US
dc.titleTherapeutic Lumbar Punctures in HIV-associated Cryptococcal Meningitis: should opening pressure direct management?en_US
dc.typeArticleen_US
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