Assessment of three new parasite lactate dehydrogenase (pan-pLDH) tests for diagnosis of uncomplicated malaria.

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dc.contributor.authorFogg, Carole
dc.contributor.authorTwesigye, Rogers
dc.contributor.authorBatwala, Vincent
dc.contributor.authorPiola, Patrice
dc.contributor.authorNabasumba, Carolyn
dc.contributor.authorKiguli, James
dc.contributor.authorMutebi, Frederick
dc.contributor.authorHook, Christa
dc.contributor.authorGuillerm, Martine
dc.contributor.authorMoody, Anthony
dc.contributor.authorGuthmann, Jean-Paul
dc.date.accessioned2021-12-15T10:04:39Z
dc.date.available2021-12-15T10:04:39Z
dc.date.issued2008
dc.description.abstractA study to assess the diagnostic capabilities of three parasite lactate dehydrogenase (pan-pLDH) tests, Vistapan®, Carestart™ and Parabank®, was conducted in Uganda. An HRP2 test, Paracheck-Pf®, and a Giemsa-stained blood film were performed with the pLDH tests for outpatients with suspected malaria. In total, 460 subjects were recruited: 248 with positive blood films and 212 with negative blood films. Plasmodium falciparum was present in 95% of infections. Sensitivity above 90% was shown by two pLDH tests, Carestart (95.6%) and Vistapan (91.9%), and specificity above 90% by Parabank (94.3%) and Carestart (91.5%). Sensitivity decreased with low parasitaemia (χ2 trend, P < 0.001); however, all tests achieved sensitivity >90% with parasitaemia ≥100/μl. All tests had good inter-reader reliability (κ > 0.95). Two weeks after diagnosis, 4–10% of pLDH tests were still positive compared with 69.7% of the HRP2 tests. All tests had similar ease of use. In conclusion, two pLDH tests performed well in diagnosing P. falciparum malaria, and all pLDH tests became negative after treatment more quickly than the HRP2. Therefore the rapid test of choice for use with artemisinin-combination therapies in this area would be one of these new pLDH tests.en_US
dc.identifier.citationFogg, C., Twesigye, R., Batwala, V., Piola, P., Nabasumba, C., Kiguli, J., ... & Guthmann, J. P. (2008). Assessment of three new parasite lactate dehydrogenase (pan-pLDH) tests for diagnosis of uncomplicated malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene, 102(1), 25-31. https://doi.org/10.1016/j.trstmh.2007.09.014en_US
dc.identifier.issn0035-9203
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/568
dc.language.isoenen_US
dc.publisherTransactions of the Royal Society of Tropical Medicine and Hygieneen_US
dc.subjectMalaria, Diagnosis, Rapid diagnostic tests, Validity, Sensitivity and specificity, Parasite lactate dehydrogenase testsen_US
dc.titleAssessment of three new parasite lactate dehydrogenase (pan-pLDH) tests for diagnosis of uncomplicated malaria.en_US
dc.typeArticleen_US
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