High HIV-1 prevalence, risk behaviours, and willingness to participate in HIV vaccine trials in fishing communities on Lake Victoria, Uganda

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dc.contributor.authorKiwanuka, Noah
dc.contributor.authorSsetaala, Ali
dc.contributor.authorMpendo, Juliet
dc.contributor.authorWambuzi, Matthias
dc.contributor.authorNanvubya, Annet
dc.contributor.authorSigirenda, Simon
dc.contributor.authorNalutaaya, Annet
dc.contributor.authorKato, Paul
dc.contributor.authorNielsen, Leslie
dc.contributor.authorKaleebu, Pontiano
dc.contributor.authorNalusiba, Josephine
dc.contributor.authorSewankambo, Nelson K
dc.date.accessioned2022-01-05T12:10:13Z
dc.date.available2022-01-05T12:10:13Z
dc.date.issued2013
dc.description.abstractHIV epidemics in sub-Saharan Africa are generalized, but high-risk subgroups exist within these epidemics. A recent study among fisher-folk communities (FFC) in Uganda showed high HIV prevalence (28.8%) and incidence (4.9/100 person-years). However, those findings may not reflect population-wide HIV rates in FFC since the study population was selected for high-risk behaviour. Between September 2011 and March 2013, we conducted a community-based cohort study to determine the population representative HIV rates and willingness to participate (WTP) in hypothetical vaccine trials among FFC, Uganda. At baseline (September 2011January 2012), a household enumeration census was done in eight fishing communities (one lakeshore and seven islands), after which a random sample of 2200 participants aged 1849 years was selected from 5360 individuals. Interviewer-administered questionnaire data were collected on HIV risk behaviours and WTP, and venous blood was collected for HIV testing using rapid HIV tests with enzyme-linked immunosorbent assay (EIA) confirmation. Adjusted prevalence proportion ratios (adj.PPRs) of HIV prevalence were determined using log-binomial regression models. Overall baseline HIV prevalence was 26.7% and was higher in women than men (32.6% vs. 20.8%, pB0.0001). Prevalence was lower among fishermen (22.4%) than housewives (32.1%), farmers (33.1%) and bar/lodge/restaurant workers (37%). The adj.PPR of HIV was higher among women than men (adj.PPR 1.50, 95%; 1.20, 1.87) and participants aged 3039 years (adj.PPR 1.40, 95%; 1.10, 1.79) and 4049 years (adj.PPR 1.41, 95%; 1.04, 1.92) compared to those aged 1824 years. Other factors associated with HIV prevalence included low education, previous marriage, polygamous marriage, alcohol and marijuana use before sex. WTP in hypothetical vaccine trials was 89.3% and was higher in men than women (91.2% vs. 87.3%, p 0.004) and among island communities compared to lakeshore ones (90.4% vs. 85.8%, p 0.004). The HIV prevalence in the general fisher-folk population in Uganda is similar to that observed in the ‘‘high-risk’’ fisher folk. FFC have very high levels of willingness to participate in future HIV vaccine trials.en_US
dc.identifier.citationKiwanuka, N., Ssetaala, A., Mpendo, J., Wambuzi, M., Nanvubya, A., Sigirenda, S., ... & Sewankambo, N. K. (2013). High HIV‐1 prevalence, risk behaviours, and willingness to participate in HIV vaccine trials in fishing communities on Lake Victoria, Uganda. Journal of the International AIDS Society, 16(1), 18621.DOI: https://doi.org/10.7448/IAS.16.1.18621en_US
dc.identifier.urihttps://doi.org/10.7448/IAS.16.1.18621
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1085
dc.language.isoenen_US
dc.publisherJournal of the International AIDS Societyen_US
dc.relation.ispartofseriesJournal of the International AIDS Society;16(1)
dc.subjectHIV-1en_US
dc.subjectWillingness to participate in HIV vaccine trialsen_US
dc.subjectFishing communitiesen_US
dc.subjectUgandaen_US
dc.titleHigh HIV-1 prevalence, risk behaviours, and willingness to participate in HIV vaccine trials in fishing communities on Lake Victoria, Ugandaen_US
dc.typeArticleen_US
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