The role of cytokines in the pathogenesis and staging of Trypanosoma brucei rhodesiense sleeping sickness

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dc.contributor.authorKato, Charles D.
dc.contributor.authorMatovu, Enock
dc.contributor.authorMugasa, Claire. M.
dc.contributor.authorNanteza, Ann
dc.contributor.authorAlibu, Vincent P.
dc.date.accessioned2023-03-07T15:54:20Z
dc.date.available2023-03-07T15:54:20Z
dc.date.issued2016
dc.description.abstractHuman African trypanosomiasis due to Trypanosoma brucei rhodesiense is invariably fatal if untreated with up to 12.3 million people at a risk of developing the disease in Sub-Saharan Africa. The disease is characterized by a wide spectrum of clinical presentation coupled with differences in disease progression and severity. While the factors determining this varied response have not been clearly characterized, inflammatory cytokines have been partially implicated as key players. In this review, we consolidate available literature on the role of specific cytokines in the pathogenesis of T. b. rhodesiense sleeping sickness and further discuss their potential as stage biomarkers. Such information would guide upcoming research on the immunology of sleeping sickness and further assist in the selection and evaluation of cytokines as disease stage or diagnostic biomarkers.en_US
dc.identifier.citationKato, C. D., Matovu, E., Mugasa, C., Nanteza, A., & Alibu, V. P. (2016). The role of cytokines in the pathogenesis and staging of Trypanosoma brucei rhodesiense sleeping sickness. Allergy, Asthma & Clinical Immunology, 12(1), 1-10.https://doi.org/10.1186/s13223-016-0113-5en_US
dc.identifier.issn1710-1492
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/8121
dc.language.isoenen_US
dc.publisherAllergy, Asthma & Clinical Immunologyen_US
dc.subjectHuman African Trypanosomiasisen_US
dc.subjectCytokinesen_US
dc.subjectImmune responseen_US
dc.subjectBiomarkersen_US
dc.subjectSleeping sicknessen_US
dc.titleThe role of cytokines in the pathogenesis and staging of Trypanosoma brucei rhodesiense sleeping sicknessen_US
dc.typeArticleen_US
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