Blood Culture Testing Outcomes among Non-Malarial Febrile Children at Antimicrobial Resistance Surveillance Sites in Uganda, 2017–2018

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dc.contributor.authorKisame, Rogers
dc.contributor.authorNajjemba, Robinah
dc.contributor.authorGriensven, Johan van
dc.contributor.authorKitutu, Freddy Eric
dc.contributor.authorTakarinda, Kudakwashe
dc.contributor.authorThekkur, Pruthu
dc.contributor.authorDelamou, Alexandre
dc.contributor.authorWalwema, Richard
dc.contributor.authorKakooza, Francis
dc.contributor.authorMugerwa, Ibrahim
dc.contributor.authorSekamatte, Musa
dc.contributor.authorRobert, Kimera
dc.contributor.authorKatairo, Thomas
dc.contributor.authorOpollo, Marc Sam
dc.contributor.authorOtita, Morgan
dc.contributor.authorLamorde, Mohammed
dc.date.accessioned2022-03-18T20:38:27Z
dc.date.available2022-03-18T20:38:27Z
dc.date.issued2018
dc.description.abstractBlood culture (BC) processes are critical to the utility of diagnostic testing, bloodstream infection (BSI) management, and antimicrobial resistance (AMR) surveillance. While Uganda has established BC guidelines, often laboratory practice does not meet the desired standards. This compromises pathogen recovery, reliability of antimicrobial susceptibility testing, and diagnostic test utility. This study assessed laboratory BC process outcomes among non-malarial febrile children below five years of age at five AMR surveillance sites in Uganda between 2017 and 2018. Secondary BC testing data was reviewed against established standards. Overall, 959 BC specimens were processed. Of these, 91% were from female patients, neonates, infants, and young children (1–48 months). A total of 37 AMR priority pathogens were identified; Staphylococcus aureus was predominant (54%), followed by Escherichia coli (19%). The diagnostic yield was low (4.9%). Only 6.3% of isolates were identified. AST was performed on 70% (18/26) of identified AMR priority isolates, and only 40% of these tests adhered to recommended standards. Interventions are needed to improve laboratory BC practices for effective patient management through targeted antimicrobial therapy and AMR surveillance in Uganda. Further research on process documentation, diagnostic yield, and a review of patient outcomes for all hospitalized febrile patients is needed.en_US
dc.identifier.citationKisame, R.; Najjemba, R.; van Griensven, J.; Kitutu, F.E.; Takarinda, K.; Thekkur, P.; Delamou, A.;Walwema, R.; Kakooza, F.; Mugerwa, I.; et al. Blood Culture Testing Outcomes among Non-Malarial Febrile Children at Antimicrobial Resistance Surveillance Sites in Uganda, 2017–2018. Trop. Med. Infect. Dis. 2021, 6, 71. https:// doi.org/10.3390/tropicalmed6020071en_US
dc.identifier.urihttps:// doi.org/10.3390/tropicalmed6020071
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/2829
dc.language.isoenen_US
dc.publisherTropical medicine & infectious diseaseen_US
dc.subjectBlood cultureen_US
dc.subjectBloodstream infectionsen_US
dc.subjectFebrile illnessen_US
dc.subjectAntimicrobial resistanceen_US
dc.subjectAntimicrobial susceptibility testingen_US
dc.subjectOperational researchen_US
dc.subjectSORT ITen_US
dc.titleBlood Culture Testing Outcomes among Non-Malarial Febrile Children at Antimicrobial Resistance Surveillance Sites in Uganda, 2017–2018en_US
dc.typeArticleen_US
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