Early Weaning of HIV-Exposed Uninfected Infants and Risk of Serious Gastroenteritis: Findings from Two Perinatal HIV Prevention Trials in Kampala, Uganda

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dc.contributor.authorMakumbi, Carolyne Onyango
dc.contributor.authorBagenda, Danstan
dc.contributor.authorMwatha, Antony
dc.contributor.authorOmer, Saad B.
dc.contributor.authorMusoke, Philippa
dc.contributor.authorMmiro, Francis
dc.contributor.authorZwerski, Sheryl L.
dc.contributor.authorKateera, Brenda Asiimwe
dc.contributor.authorMusisi, Maria
dc.contributor.authorFowler, Mary Glenn
dc.contributor.authorJackson, J. Brooks
dc.contributor.authorGuay, Laura A.
dc.date.accessioned2022-01-31T12:56:07Z
dc.date.available2022-01-31T12:56:07Z
dc.date.issued2010
dc.description.abstractTo assess serious gastroenteritis risk and mortality associated with early cessation of breastfeeding in infants enrolled in two prevention-of-maternal-to-child-HIV-transmission trials in Uganda.We used hazard rates to evaluate serious gastroenteritis events by month of age and mortality among HIV-exposed uninfected infants enrolled in the HIVNET 012 (1997-2001) and HIVIGLOB/NVP (2004-2007) trials. HIV-infected mothers were counseled using local infant feeding guidelines current at the time.Breastfeeding cessation occurred earlier in HIVIGLOB/NVP compared to HIVNET 012 (median 4.0 vs. 9.3 months, p<0.001). Rates of serious gastroenteritis were higher in HIVIGLOB/NVP (8.0/1000 child-months) compared to HIVNET 012 (3.1/1000 child-months; p < 0.001). Serious gastroenteritis events also peaked earlier at 3-4 and 7-8 months (16.2/1000 and 15.0/1000 child-months, respectively) compared to HIVNET 012 at 9 to10 months (20.8/1000 child-months). All cause-infant mortality did not statistically differ between the HIVIGLOB/NVP and the HIVNET 012 trials [3.2/1000 versus 2.0/1000 child-months respectively, (p=0.10)]Early breastfeeding cessation seen in the HIVIGLOB/NVP trial was associated with increased risk of serious gastroenteritis among HIV-exposed uninfected infants when compared to later breastfeeding cessation in the HIVNET 012 trial. Testing interventions which could decrease HIV transmission through breastfeeding and allow safe breastfeeding into the second year of life are urgently needed.en_US
dc.identifier.citationOnyango-Makumbi, C., Bagenda, D., Mwatha, A., Omer, S. B., Musoke, P., Mmiro, F., ... & Guay, L. A. (2010). Early weaning of HIV-exposed uninfected infants and risk of serious gastroenteritis: findings from two perinatal HIV prevention trials in Kampala, Uganda. Journal of acquired immune deficiency syndromes (1999), 53(1), 20.doi: 10.1097/QAI.0b013e3181bdf68een_US
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1674
dc.language.isoenen_US
dc.publisherJournal of acquired immune deficiency syndromesen_US
dc.subjectHIV, infants, breastfeeding cessation, serious gastroenteritis, mortality, Ugandaen_US
dc.titleEarly Weaning of HIV-Exposed Uninfected Infants and Risk of Serious Gastroenteritis: Findings from Two Perinatal HIV Prevention Trials in Kampala, Ugandaen_US
dc.typeArticleen_US
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