Novel Adenoviruses in Wild Primates: a High Level of Genetic Diversity and Evidence of Zoonotic Transmissions

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dc.contributor.authorWevers, Diana
dc.contributor.authorMetzger, Sonja
dc.contributor.authorBabweteera, Fred
dc.contributor.authorBieberbach, Marc
dc.contributor.authorBoesch, Christophe
dc.contributor.authorMugisha, Lawrence
dc.contributor.authorEhlers, Bernhard
dc.date.accessioned2022-11-27T11:33:51Z
dc.date.available2022-11-27T11:33:51Z
dc.date.issued2011
dc.description.abstractAdenoviruses (AdVs) broadly infect vertebrate hosts, including a variety of nonhuman primates (NHPs). In the present study, we identified AdVs in NHPs living in their natural habitats, and through the combination of phylogenetic analyses and information on the habitats and epidemiological settings, we detected possible horizontal transmission events between NHPs and humans. Wild NHPs were analyzed with a pan-primate AdV-specific PCR using a degenerate nested primer set that targets the highly conserved adenovirus DNA polymerase gene. A plethora of novel AdV sequences were identified, representing at least 45 distinct AdVs. From the AdV-positive individuals, 29 nearly complete hexon genes were amplified and, based on phylogenetic analysis, tentatively allocated to all known human AdV species (Human adenovirus A to Human adenovirus G [HAdV-A to -G]) as well as to the only simian AdV species (Simian adenovirus A [SAdV-A]). Interestingly, five of the AdVs detected in great apes grouped into the HAdV-A, HAdV-D, HAdV-F, or SAdV-A clade. Furthermore, we report the first detection of AdVs in New World monkeys, clustering at the base of the primate AdV evolutionary tree. Most notably, six chimpanzee AdVs of species HAdV-A to HAdV-F revealed a remarkably close relationship to human AdVs, possibly indicating recent interspecies transmission events.en_US
dc.identifier.citationWevers, D., Metzger, S., Babweteera, F., Bieberbach, M., Boesch, C., Cameron, K., ... & Ehlers, B. (2011). Novel adenoviruses in wild primates: a high level of genetic diversity and evidence of zoonotic transmissions. Journal of virology, 85(20), 10774-10784. doi:10.1128/JVI.00810-11en_US
dc.identifier.other10.1128/JVI.00810-11
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/5464
dc.language.isoenen_US
dc.publisherJournal of virologyen_US
dc.subjectNovel Adenovirusesen_US
dc.subjectWild Primatesen_US
dc.subjectGenetic Diversityen_US
dc.subjectEvidence of Zoonotic Transmissionsen_US
dc.titleNovel Adenoviruses in Wild Primates: a High Level of Genetic Diversity and Evidence of Zoonotic Transmissionsen_US
dc.typeArticleen_US
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