Significant pharmacokinetic interactions between artemether/lumefantrine and efavirenz or nevirapine in HIV-infected Ugandan adults

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dc.contributor.authorByakika-Kibwika, Pauline
dc.contributor.authorLamorde, Mohammed
dc.contributor.authorMayito, Jonathan
dc.contributor.authorNabukeera, Lillian
dc.contributor.authorNamakula, Rhoda
dc.contributor.authorMayanja-Kizza, Harriet
dc.contributor.authorKatabira, Elly
dc.contributor.authorNtale, Muhammad
dc.contributor.authorPakker, Nadine
dc.contributor.authorRyan, Mairin
dc.contributor.authorHanpithakpong, Warunee
dc.contributor.authorTarning, Joel
dc.contributor.authorLindegardh, Niklas
dc.contributor.authorVries, Peter J. de
dc.contributor.authorKhoo, Saye
dc.contributor.authorBack, David
dc.date.accessioned2022-01-14T08:40:06Z
dc.date.available2022-01-14T08:40:06Z
dc.date.issued2012
dc.description.abstractCo-administration of artemether/lumefantrine with antiretroviral therapy has potential for pharmacokinetic drug interactions. We investigated drug–drug interactions between artemether/lumefantrine and efavirenz or nevirapine. Methods: We performed a cross-over study in which HIV-infected adults received standard six-dose artemether/ lumefantrine 80/480 mg before and at efavirenz or nevirapine steady state. Artemether, dihydroartemisinin, lumefantrine, efavirenz and nevirapine plasma concentrations were measured and compared.en_US
dc.identifier.citationByakika-Kibwika, P., Lamorde, M., Mayito, J., Nabukeera, L., Namakula, R., Mayanja-Kizza, H., ... & Merry, C. (2012). Significant pharmacokinetic interactions between artemether/lumefantrine and efavirenz or nevirapine in HIV-infected Ugandan adults. Journal of Antimicrobial Chemotherapy, 67(9), 2213-2221. doi:10.1093/jac/dks207en_US
dc.identifier.other10.1093/jac/dks207
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1277
dc.language.isoenen_US
dc.publisherJournal of Antimicrobial Chemotherapyen_US
dc.subjectAntimalarialen_US
dc.subjectAntiretroviralen_US
dc.subjectMalariaen_US
dc.subjectDrugsen_US
dc.titleSignificant pharmacokinetic interactions between artemether/lumefantrine and efavirenz or nevirapine in HIV-infected Ugandan adultsen_US
dc.typeArticleen_US
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