Traditional Herbal Medicine Use Associated with Liver Fibrosis in Rural Rakai, Uganda

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dc.contributor.authorAuerbach, Brandon J.
dc.contributor.authorReynolds, Steven J.
dc.contributor.authorLamorde, Mohammed
dc.contributor.authorMerry, Concepta
dc.contributor.authorKukunda-Byobona, Collins
dc.contributor.authorOcama, Ponsiano
dc.contributor.authorSemeere, Aggrey S.
dc.contributor.authorNdyanabo, Anthony
dc.contributor.authorBoaz, Iga
dc.contributor.authorKiggundu, Valerian
dc.contributor.authorNalugoda, Fred
dc.contributor.authorGray, Ron H.
dc.contributor.authorWawer, Maria J.
dc.contributor.authorThomas, David L.
dc.contributor.authorKirk, Gregory D.
dc.contributor.authorQuinn, Thomas C.
dc.contributor.authorStabinski, Lara
dc.date.accessioned2022-05-01T21:38:31Z
dc.date.available2022-05-01T21:38:31Z
dc.date.issued2012
dc.description.abstractTraditional herbal medicines are commonly used in sub-Saharan Africa and some herbs are known to be hepatotoxic. However little is known about the effect of herbal medicines on liver disease in sub-Saharan Africa. Methods: 500 HIV-infected participants in a rural HIV care program in Rakai, Uganda, were frequency matched to 500 HIVuninfected participants. Participants were asked about traditional herbal medicine use and assessed for other potential risk factors for liver disease. All participants underwent transient elastography (FibroScanH) to quantify liver fibrosis. The association between herb use and significant liver fibrosis was measured with adjusted prevalence risk ratios (adjPRR) and 95% confidence intervals (CI) using modified Poisson multivariable logistic regression. Results: 19 unique herbs from 13 plant families were used by 42/1000 of all participants, including 9/500 HIV-infected participants. The three most-used plant families were Asteraceae, Fabaceae, and Lamiaceae. Among all participants, use of any herb (adjPRR = 2.2, 95% CI 1.3–3.5, p = 0.002), herbs from the Asteraceae family (adjPRR = 5.0, 95% CI 2.9–8.7, p,0.001), and herbs from the Lamiaceae family (adjPRR = 3.4, 95% CI 1.2–9.2, p = 0.017) were associated with significant liver fibrosis. Among HIV infected participants, use of any herb (adjPRR = 2.3, 95% CI 1.0–5.0, p = 0.044) and use of herbs from the Asteraceae family (adjPRR = 5.0, 95% CI 1.7–14.7, p = 0.004) were associated with increased liver fibrosis. Conclusions: Traditional herbal medicine use was independently associated with a substantial increase in significant liver fibrosis in both HIV-infected and HIV-uninfected study participants. Pharmacokinetic and prospective clinical studies are needed to inform herb safety recommendations in sub-Saharan Africa. Counseling about herb use should be part of routine health counseling and counseling of HIV-infected persons in Uganda.en_US
dc.identifier.citationAuerbach BJ, Reynolds SJ, Lamorde M, Merry C, Kukunda-Byobona C, et al. (2012) Traditional Herbal Medicine Use Associated with Liver Fibrosis in Rural Rakai, Uganda. PLoS ONE 7(11): e41737. doi:10.1371/journal.pone.0041737en_US
dc.identifier.other10.1371/journal.pone.0041737
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/3106
dc.language.isoenen_US
dc.publisherPLoS ONEen_US
dc.subjectTraditional Herbal Medicineen_US
dc.subjectLiver Fibrosisen_US
dc.subjectRural Rakaien_US
dc.subjectUgandaen_US
dc.titleTraditional Herbal Medicine Use Associated with Liver Fibrosis in Rural Rakai, Ugandaen_US
dc.typeArticleen_US
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