Biobanking: Strengthening Uganda’s Rapid Response to COVID-19 and Other Epidemics

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dc.contributor.authorKamulegeya, Rogers
dc.contributor.authorKateete, David Patrick
dc.contributor.authorBagaya, Bernard S.
dc.contributor.authorNasinghe, Emmanuel
dc.contributor.authorMuttamba, Winters
dc.contributor.authorNsubuga, Gideon
dc.contributor.authorKigozi, Edgar
dc.contributor.authorAshaba Katabazi, Fred
dc.contributor.authorNakwagala, Fred
dc.contributor.authorKalungi, Sam
dc.contributor.authorByamugisha, Josaphat
dc.contributor.authorWorodria, William
dc.contributor.authorMagala, Rose
dc.contributor.authorKirenga, Bruce
dc.contributor.authorJoloba, Moses L.
dc.date.accessioned2022-05-12T09:28:46Z
dc.date.available2022-05-12T09:28:46Z
dc.date.issued2021
dc.description.abstractSARS-CoV-2 is a fatal disease of global public health concern. Measures to reduce its spread critically depend on timely and accurate diagnosis of virus-infected individuals. Biobanks can have a pivotal role in elucidating disease etiology, translation, and advancing public health. In this article, we show how a biobank has been a critical resource in the rapid response to coronavirus disease of 2019 (COVID-19) in Uganda. Materials and Methods: The Integrated Biorepository of H3Africa Uganda established a COVID-19 biobank. Standard Operating Procedures for sample and data collection, sample processing, and storage were developed. An e-questionnaire data tool was used to collect sociodemographic factors. Samples were collected at 7-day intervals from patients, analyzed for key parameters, processed, annotated, characterized, and stored at appropriate temperatures. Results: Stored samples have been used in validation of 17 diagnostic kits, the Cepheid Xpert Xpress SARSCoV- 2 assay, as well as a sample pooling technique for mass screening and polymerase chain reaction assay validation. Kits that passed validation were deployed for mass screening boosting early detection, isolation, and treatment of COVID-19 cases. Also, 10 applications from researchers and biotech companies have been received and approved and 4 grants have been awarded Conclusion: The CoV-Bank has proven to be an invaluable resource in the fight against the COVID-19 pandemic in Uganda, as samples have been resources in the validation and development of COVID-19 diagnostic tools, which are important in tracing and isolation of infected cases to confront, delay, and stop the spread of the SARS-CoV-2 virus.en_US
dc.identifier.citationKamulegeya, R., Kateete, D. P., Bagaya, B. S., Nasinghe, E., Muttamba, W., Nsubuga, G., ... & Joloba, M. L. (2021). Biobanking: Strengthening Uganda's Rapid Response to COVID-19 and Other Epidemics. Biopreservation and Biobanking. DOI: 10.1089/bio.2021.0022en_US
dc.identifier.other10.1089/bio.2021.0022
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/3226
dc.language.isoenen_US
dc.publisherBiopreservation and Biobankingen_US
dc.subjectBiobankingen_US
dc.subjectCOVID-19en_US
dc.subjectPandemicen_US
dc.subjectDiagnosticsen_US
dc.subjectRapid responseen_US
dc.titleBiobanking: Strengthening Uganda’s Rapid Response to COVID-19 and Other Epidemicsen_US
dc.typeArticleen_US
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