Expanded Phase I safety and acceptability study of 6% cellulose sulfate vaginal gel

An expanded Phase I trial was performed to assess the safety and acceptability of 6% cellulose sulfate gel (CS) in comparison with K-Y Jelly. Sexually abstinent (cohort I) and sexually active (cohort II) women in India, Nigeria and Uganda applied 3.5 ml of either 6% CS gel or K-Y Jelly for seven consecutive days. Safety was assessed by symptoms and signs (including colposcopy) of genital irritation, review of adverse events, and by changes in vaginal health as assessed by microscopy.

Keywords

Cellulose sulphate, Microbicide, Vaginal gel, HIV prevention, Sexually transmitted infections, Phase I clinical trial

Citation

Malonza, I. M., Mirembe, F., Nakabiito, C., Odusoga, L. O., Osinupebi, O. A., Hazari, K., ... & Van Damme, L. (2005). Expanded Phase I safety and acceptability study of 6% cellulose sulfate vaginal gel. Aids, 19(18), 2157-2163.