Non-adherence to anti-TB drugs among TB/HIV co-infected patients in Mbarara Hospital Uganda: Prevalence and associated factors

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dc.contributor.authorAmuha, Monica G.
dc.contributor.authorKutyabami, Paul
dc.contributor.authorKitutu, Freddy E.
dc.contributor.authorOdoi-Adome, Richard
dc.contributor.authorKalyango, Joan N.
dc.date.accessioned2022-02-02T20:35:26Z
dc.date.available2022-02-02T20:35:26Z
dc.date.issued2009
dc.description.abstractNon-adherence to treatment remains a major obstacle to efficient tuberculosis control in developing countries. The dual infection of Tuberculosis and HIV presents further adherence problems because of high pill burden and adverse effects. This poses a risk of increased multi-drug resistant TB. However, the prevalence of non-adherence and its associated factors have not been studied in these patients in Uganda. Objectives: To determine the prevalence and factors associated with non-adherence to anti-TB drugs among TB/HIV co-infected patients in Mbarara hospital. Methods: A cross-sectional study with qualitative and quantitative data collection methods was conducted among TB/HIV coinfected adults in Mbarara hospital from January to March 2008. Consecutive sampling was used to select 140 participants. Adherence was assessed over a 5-day period prior to the interview using patients self-reports. Data was collected using an interviewer administered questionnaire. Qualitative data was collected through key informant interviews using a topic guide and was analyzed manually. Quantitative data was analyzed using STATA version 8. Logistic regression was used to determine factors associated with nonadherence. Results: The prevalence of non-adherence was 25% (95% CI=17.8-32%). Being on continuous phase of the TB regimen was significantly associated with non-adherence (OR=6.24, p<0.001). Alcohol consumption, being on antiretroviral therapy and smoking confounded the relationship between stage of the TB regimen and non-adherence. Conclusion: The prevalence of non-adherence was high. Patients that are on continuous phase of TB treatment should be supported to continue taking their drugs. In addition, patients that drink alcohol; smoke and those not on ART should be targeted with interventions to improve adherence.en_US
dc.identifier.citationAmuha, M. G., Kutyabami, P., Kitutu, F. E., Odoi-Adome, R., & Kalyango, J. N. (2009). Non-adherence to anti-TB drugs among TB/HIV co-infected patients in Mbarara Hospital Uganda: prevalence and associated factors. African health sciences, 9(2).en_US
dc.identifier.urihttps://www.ajol.info/index.php/ahs/article/view/47806
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1800
dc.language.isoenen_US
dc.publisherAfrican health sciencesen_US
dc.subjectAnti-TB drugsen_US
dc.subjectTB/HIV co-infected patientsen_US
dc.subjectMbarara Hospital Ugandaen_US
dc.titleNon-adherence to anti-TB drugs among TB/HIV co-infected patients in Mbarara Hospital Uganda: Prevalence and associated factorsen_US
dc.typeArticleen_US
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