Lean Tissue Mass Wasting is Associated With Increased Risk of Mortality Among Women With Pulmonary Tuberculosis in Urban Uganda

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dc.contributor.authorMupere, Ezekiel
dc.contributor.authorMalone, Lashaunda
dc.contributor.authorZalwango, Sarah
dc.contributor.authorChiunda, Allan
dc.contributor.authorOkwera, Alphonse
dc.contributor.authorParraga, Isabel
dc.contributor.authorStein, Catherine M.
dc.contributor.authorTisch, Daniel J.
dc.contributor.authorMugerwa, Roy
dc.contributor.authorBoom, W. Henry
dc.contributor.authorMayanja, Harriet
dc.contributor.authorWhalen, Christopher C.
dc.date.accessioned2021-12-10T11:59:37Z
dc.date.available2021-12-10T11:59:37Z
dc.date.issued2012
dc.description.abstractOBJECTIVES: We assessed the impact of wasting on survival in patients with tuberculosis by using a precise height-normalized lean tissue mass index (LMI) estimated by bioelectrical impedance analysis and body mass index (BMI). METHODS: In a retrospective cohort study, 747 adult pulmonary patients with tuberculosis who were screened for HIV and nutritional status were followed for survival. RESULTS: Of 747 patients, 310 had baseline wasting by BMI (kg/m2) and 103 by LMI (kg/m2). Total deaths were 105. Among men with reduced BMI, risk of death was 70% greater (hazard ratio [HR] 1.7, 95% confidence interval [95% CI] 1.03–2.81) than in men with normal BMI. Survival did not differ by LMI among men (HR 1.1; 95% CI 0.5–2.9). In women, both the BMI and LMI were associated with survival. Among women with reduced BMI, risk of death was 80% greater (HR 1.8; 95% CI 0.9–3.5) than in women with normal BMI; risk of death was 5-fold greater (HR 5.0; 95% CI 1.6–15.9) for women with low LMI compared with women with normal LMI. CONCLUSIONS: Wasting assessed by reduced BMI is associated with an increased risk for death among both men and women whereas reduced LMI is among women with tuberculosis.en_US
dc.identifier.citationMupere, E., Malone, L., Zalwango, S., Chiunda, A., Okwera, A., Parraga, I., ... & Whalen, CC (2012). Lean tissue mass wasting is associated with increased risk of mortality among women with pulmonary tuberculosis in urban Uganda. Annals of epidemiology , 22 (7), 466-473.en_US
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1047279712001019
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/250
dc.language.isoenen_US
dc.publisherElsevier Inc.en_US
dc.subjectTuberculosis,en_US
dc.subjectSurvival,en_US
dc.subjectWasting,en_US
dc.subjectLean Tissue Mass Index,en_US
dc.subjectBody Mass Index,en_US
dc.subjectBioelectrical Impedance Analysis.en_US
dc.titleLean Tissue Mass Wasting is Associated With Increased Risk of Mortality Among Women With Pulmonary Tuberculosis in Urban Ugandaen_US
dc.typeArticleen_US
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