Doxorubicin and Paclitaxel Loaded Microbubbles for Ultrasound Triggered Drug Delivery

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dc.contributor.authorCochran, Michael C.
dc.contributor.authorEisenbrey, John
dc.contributor.authorOuma, Richard O.
dc.contributor.authorSoulen, Michael
dc.contributor.authorWheatley, Margaret A.
dc.date.accessioned2022-08-31T15:05:00Z
dc.date.available2022-08-31T15:05:00Z
dc.date.issued2011
dc.description.abstractA polymer ultrasound contrast agent (UCA) developed in our lab has been shown to greatly reduce in size when exposed to ultrasound, resulting in nanoparticles less than 400 nm in diameter capable of escaping the leaky vasculature of a tumor to provide a sustained release of drug. Previous studies with the hydrophilic drug doxorubicin (DOX) demonstrated enhanced drug delivery to tumors when triggered with ultrasound. However the therapeutic potential has been limited due to the relatively low payload of DOX. This study compares the effects of loading the hydrophobic drug paclitaxel (PTX) on the agent's acoustic properties, drug payload, tumoricidal activity, and the ability to deliver drugs through 400 nm pores. A maximum payload of 129.46 ± 1.80 μg PTX/mg UCA (encapsulation efficiency 71.92 ± 0.99%) was achieved, 20 times greater than the maximum payload of DOX (6.2 μg/mg), while maintaining the acoustic properties. In vitro, the tumoricidal activity of paclitaxel loaded UCA exposed to ultrasound was significantly greater than controls not exposed to ultrasound (p < 0.0016). This study has shown that PTX loaded UCA triggered with focused ultrasound have the potential to provide a targeted and sustained delivery of drug to tumors.en_US
dc.identifier.citationCochran, M. C., Eisenbrey, J., Ouma, R. O., Soulen, M., & Wheatley, M. A. (2011). Doxorubicin and paclitaxel loaded microbubbles for ultrasound triggered drug delivery. International journal of pharmaceutics, 414(1-2), 161-170.https://doi.org/10.1016/j.ijpharm.2011.05.030en_US
dc.identifier.issn0378-5173
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/4496
dc.language.isoenen_US
dc.publisherInternational journal of pharmaceuticsen_US
dc.subjectUltrasound contrast agent; Microbubble; Paclitaxel; Nanoparticle; Targeted drug deliveryen_US
dc.titleDoxorubicin and Paclitaxel Loaded Microbubbles for Ultrasound Triggered Drug Deliveryen_US
dc.typeArticleen_US
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