Treatment success rate among adult pulmonary tuberculosis patients in sub- Saharan Africa: a systematic review and meta-analysis

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dc.contributor.authorIzudi, Jonathan
dc.contributor.authorSemakula, Daniel
dc.contributor.authorSennono, Richard
dc.contributor.authorTamwesigire, Imelda K
dc.contributor.authorBajunirwe, Francis
dc.date.accessioned2022-06-09T20:32:26Z
dc.date.available2022-06-09T20:32:26Z
dc.date.issued2019
dc.description.abstractsummarise treatment success rate (TSR) among adult bacteriologically confirmed pulmonary tuberculosis (BC-PTB) patients in sub-Saharan Africa (SSA).We searched MEDLINE, EMBASE, Google Scholar and Web of Science electronic databases for eligible studies published in the decade between 1 July 2008 and 30 June 2018. Two independent reviewers extracted data and disagreements were resolved by consensus with a third reviewer. We used random-effects model to pool TSR in Stata V.15, and presented results in a forest plot with 95% CIs and predictive intervals. We assessed heterogeneity with Cochrane’s (Q) test and quantified with I-squared values. We checked publication bias with funnel plots and Egger’s test. We performed subgroup, meta-regression, sensitivity and cumulative meta-analyses. Adults 15 years and older, new and retreatment BC-PTB patients.TSR measured as the proportion of smear-positive TB cases registered under directly observed therapy in a given year that successfully completed treatment, either with bacteriologic evidence of success (cured) or without (treatment completed).31 studies (2 cross-sectional, 1 case–control, 17 retrospective cohort, 6 prospective cohort and 5 randomised controlled trials) involving 18 194 participants were meta-analysed. 28 of the studies had good quality data. Egger’s test indicated no publication bias, rather small study effect. The pooled TSR was 76.2% (95% CI 72.5% to 79.8%; 95% prediction interval, 50.0% to 90.0%, I2 statistics=96.9%). No single study influenced the meta-analytical results or conclusions. Between 2008 and 2018, a gradual but steady decline in TSR occurred in SSA but without statistically significant time trend variation (p=0.444). The optimum TSR of 90% was not achieved.Over the past decade, TSR was heterogeneous and suboptimal in SSA, suggesting context and country-specific strategies are needed to end the TB epidemic.en_US
dc.identifier.citationIzudi, J., Semakula, D., Sennono, R., Tamwesigire, I. K., & Bajunirwe, F. (2019). Treatment success rate among adult pulmonary tuberculosis patients in sub-Saharan Africa: a systematic review and meta-analysis. BMJ open, 9(9), e029400.http://dx.doi.org/10.1136/bmjopen-2019-029400en_US
dc.identifier.issn2044-6055
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/3871
dc.language.isoenen_US
dc.publisherBMJ openen_US
dc.titleTreatment success rate among adult pulmonary tuberculosis patients in sub- Saharan Africa: a systematic review and meta-analysisen_US
dc.typeArticleen_US
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