Dosing of Ceftriaxone and Metronidazole for Children With Severe Acute Malnutrition

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dc.contributor.authorStanding, Joseph F.
dc.contributor.authorOngas, Martin O.
dc.contributor.authorOgwang, Caroline
dc.contributor.authorKagwanja, Nancy
dc.contributor.authorMurunga, Sheila
dc.contributor.authorMwaringa, Shalton
dc.contributor.authorAli, Rehema
dc.contributor.authorMturi, Neema
dc.contributor.authorTimbwa, Moline
dc.contributor.authorManyasi, Christine
dc.contributor.authorMwalekwa, Laura
dc.contributor.authorBandika, Victor L.
dc.contributor.authorOgutu, Bernhards
dc.contributor.authorWaichungo, Joseph
dc.contributor.authorKipper, Karin
dc.contributor.authorBerkley, James A.
dc.date.accessioned2022-04-29T14:22:36Z
dc.date.available2022-04-29T14:22:36Z
dc.date.issued2018
dc.description.abstractInfants and young children with severe acute malnutrition (SAM) are treated with empiric broad-spectrumantimicrobials. Parenteral ceftriaxone is currently a second-line agent for invasive infection. Oral metronidazole principally targets small intestinal bacterial overgrowth. Children with SAM may have altered drug absorption, distribution, metabolism, and elimination. Population pharmacokinetics of ceftriaxone and metronidazole were studied, with the aimof recommending optimal dosing. Eighty-one patients with SAM (aged 2–45 months) provided 234 postdose pharmacokinetic samples for total ceftriaxone, metronidazole, and hydroxymetronidazole. Ceftriaxone protein binding was alsomeasured in 190 of these samples. A three-compartment model adequately described free ceftriaxone, with a Michaelis–Menten model for concentration and albumin-dependent protein binding. A one-compartment model was used for both metronidazole and hydroxymetronidazole, with only 1% of hydroxymetronidazole predicted to be formed during first-pass. Simulations showed 80mg/kg once daily of ceftriaxone and 12.5mg/kg twice daily ofmetronidazole were sufficient to reach therapeutic targets.en_US
dc.identifier.citationStanding, J. F., Ongas, M. O., Ogwang, C., Kagwanja, N., Murunga, S., Mwaringa, S., ... & FLACSAM‐PK Study Group. (2018). Dosing of ceftriaxone and metronidazole for children with severe acute malnutrition. Clinical Pharmacology & Therapeutics, 104(6), 1165-1174. doi:10.1002/cpt.1078en_US
dc.identifier.other10.1002/cpt.1078
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/2981
dc.language.isoenen_US
dc.publisherClinical Pharmacology & Therapeuticsen_US
dc.subjectDosingen_US
dc.subjectCeftriaxoneen_US
dc.subjectMetronidazoleen_US
dc.subjectChildrenen_US
dc.subjectSevere Acute Malnutritionen_US
dc.titleDosing of Ceftriaxone and Metronidazole for Children With Severe Acute Malnutritionen_US
dc.typeArticleen_US
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