The dawn of a cure for sickle cell disease through CRISPR-based treatment: A critical test of equity in public health genomics

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dc.contributor.authorMboowa, Gerald
dc.contributor.authorSserwadda, Ivan
dc.contributor.authorKanyerezi, Stephen
dc.contributor.authorTukwasibwe, Stephen
dc.contributor.authorKidenya, Benson
dc.date.accessioned2025-05-03T12:33:09Z
dc.date.available2025-05-03T12:33:09Z
dc.date.issued2024
dc.description.abstractEquity in access to genomic technologies, resources, and products remains a great challenge. This was evident especially during the coronavirus disease 2019 (COVID‐19) pandemic when the majority of lower middle‐income countries were unable to achieve at least 10% population vaccination coverage during initial COVID‐19 vaccine rollouts, despite the rapid development of those vaccines. Sickle cell disease (SCD) is an inherited monogenic red blood cell disorder that affects hemoglobin, the protein that carries oxygen through the body. Globally, the African continent carries the highest burden of SCD with at least 240,000 children born each year with the disease. SCD has evolved from a treatable to a curable disease. Recently, the UK medical regulator approved its cure through clustered regularly interspaced short palindromic repeat (CRISPR)‐based treatment, whereas the US Food and Drug Administration has equally approved two SCD gene therapies. This presents a remarkable opportunity to demonstrate equity in public health genomics. This CRISPR‐based treatment is expensive and therefore, a need for an ambitious action to ensure that they are affordable and accessible where they are needed most and stand to save millions of lives.
dc.identifier.citationMboowa, G., Sserwadda, I., Kanyerezi, S., Tukwasibwe, S., & Kidenya, B. (2024). The dawn of a cure for sickle cell disease through CRISPR‐based treatment: A critical test of equity in public health genomics. Annals of Human Genetics.
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/abs/10.1111/ahg.12558
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/11370
dc.language.isoen
dc.publisherAnnals of Human Genetics
dc.titleThe dawn of a cure for sickle cell disease through CRISPR-based treatment: A critical test of equity in public health genomics
dc.typeArticle
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