Coinfection of Ugandan Red Colobus (Procolobus [Piliocolobus] rufomitratus tephrosceles) with Novel, Divergent Delta-, Lenti-, and Spumaretroviruses

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dc.contributor.authorGoldberg, Tony L.
dc.contributor.authorSintasath, David M.
dc.contributor.authorChapman, Colin A.
dc.contributor.authorCameron, Kenneth M.
dc.contributor.authorKaresh, William B.
dc.contributor.authorTang, Shaohua
dc.contributor.authorWolfe, Nathan D.
dc.contributor.authorRwego, Innocent B.
dc.contributor.authorTing, Nelson
dc.contributor.authorSwitzer, William M.
dc.date.accessioned2022-02-04T15:14:49Z
dc.date.available2022-02-04T15:14:49Z
dc.date.issued2009
dc.description.abstractNonhuman primates host a plethora of potentially zoonotic microbes, with simian retroviruses receiving heightened attention due to their roles in the origins of human immunodeficiency viruses type 1 (HIV-1) and HIV-2. However, incomplete taxonomic and geographic sampling of potential hosts, especially the African colobines, has left the full range of primate retrovirus diversity unexplored. Blood samples collected from 31 wild-living red colobus monkeys (Procolobus [Piliocolobus] rufomitratus tephrosceles) from Kibale National Park, Uganda, were tested for antibodies to simian immunodeficiency virus (SIV), simian T-cell lymphotrophic virus (STLV), and simian foamy virus (SFV) and for nucleic acids of these same viruses using genus-specific PCRs. Of 31 red colobus tested, 22.6% were seroreactive to SIV, 6.4% were seroreactive to STLV, and 97% were seroreactive to SFV. Phylogenetic analyses of SIV polymerase (pol), STLV tax and long terminal repeat (LTR), and SFV pol and LTR sequences revealed unique SIV and SFV strains and a novel STLV lineage, each divergent from corresponding retroviral lineages previously described in Western red colobus (Procolobus badius badius) or black-and-white colobus (Colobus guereza). Phylogenetic analyses of host mitochondrial DNA sequences revealed that red colobus populations in East and West Africa diverged from one another approximately 4.25 million years ago. These results indicate that geographic subdivisions within the red colobus taxonomic complex exert a strong influence on etroviral phylogeny and that studying retroviral diversity in closely related primate taxa should be particularly informative for understanding host-virus coevolution.en_US
dc.identifier.citationGoldberg, T. L., Sintasath, D. M., Chapman, C. A., Cameron, K. M., Karesh, W. B., Tang, S., ... & Switzer, W. M. (2009). Coinfection of Ugandan red colobus (Procolobus [Piliocolobus] rufomitratus tephrosceles) with novel, divergent delta-, lenti-, and spumaretroviruses. Journal of virology, 83(21), 11318-11329. https://doi.org/10.1128/JVI.02616-08en_US
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1911
dc.language.isoenen_US
dc.publisherJournal of virologyen_US
dc.titleCoinfection of Ugandan Red Colobus (Procolobus [Piliocolobus] rufomitratus tephrosceles) with Novel, Divergent Delta-, Lenti-, and Spumaretrovirusesen_US
dc.typeArticleen_US
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