Traditional Medicinal Uses, Phytoconstituents, Bioactivities, and Toxicities of Erythrina abyssinica Lam. ex DC. (Fabaceae): A Systematic Review
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Date
2021
Journal Title
Journal ISSN
Volume Title
Publisher
Evidence-Based Complementary and Alternative Medicine
Abstract
Many studies have been undertaken on the medicinal values of Erythrina abyssinica Lam. ex DC. (Fabaceae). )e
details, however, are highly fragmented in different journals, libraries, and other publication media. )is study was therefore
conducted to provide a comprehensive report on its ethnobotany, ethnomedicinal uses, phytochemicals, and the available
pharmacological evidence supporting its efficacy and safety in traditional medicine. Method. We collected data using a
PROSPERO registered systematic review protocol on the ethnobotany, phytochemistry, and ethnopharmacology of Erythrina
abyssinica from 132 reports that were retrieved from electronic databases. Documented local names, morphology, growth habit
and habitat, ethnomedicinal and nonmedicinal uses, diseases treated, parts used, method of preparation and administration,
extraction and chemical identity of isolated compounds, and efficacy and toxicity of extracts and isolated compounds were
captured. Numerical data were summarized into means, percentages, and frequencies and presented as graphs and tables. Results.
Erythrina abyssinica is harvested by traditional herbal medicine practitioners in East, Central, and South African communities to
prepare herbal remedies for various human and livestock ailments. )ese include bacterial and fungal infections, tuberculosis,
malaria, HIV/AIDS, diarrhea, cancer, meningitis, inflammatory diseases, urinary tract infections, wounds, diabetes mellitus, and
skin and soft tissue injuries. Different extracts and phytochemicals from parts of E. abyssinica have been scientifically proven to
possess anti-inflammatory, antibacterial, antioxidant, antiplasmodial, antiproliferative, antifungal, antimycobacterial, antidiarrheal,
anti-HIV 1, antidiabetic, and antiobesity activities. )is versatile pharmacological activity is due to the abundant flavonoids, alkaloids, and terpenoids present in its different parts. Conclusion. Erythrina abyssinica is an important ethnomedicinal plant in
Africa harboring useful pharmacologically active phytochemicals against various diseases with significant efficacies and minimal
toxicity to mammalian cells. )erefore, this plant should be conserved and its potential to provide novel molecules against diseases
be explored further. Clinical trials that evaluate the efficacy and safety of extracts and isolated compounds from E. abyssinica
are recommended.
Description
Keywords
Traditional Medicinal Uses, Phytoconstituents, Bioactivities, Toxicities, Erythrina abyssinica Lam. ex DC. (Fabaceae)
Citation
Obakiro, S. B., Kiprop, A., Kigondu, E., K’Owino, I., Odero, M. P., Manyim, S., ... & Bunalema, L. (2021). Traditional medicinal Uses, phytoconstituents, bioactivities, and toxicities of Erythrina abyssinica Lam. ex DC.(fabaceae): a systematic review. Evidence-Based Complementary and Alternative Medicine, 2021, 1-43. https://doi.org/10.1155/2021/5513484