Umbilical vein oxytocin for the treatment of retained placenta (Release Study): a double-blind, randomised controlled trial

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dc.contributor.authorWeeks, Andrew D.
dc.contributor.authorAlia, Godfrey
dc.contributor.authorVernon, Gillian
dc.contributor.authorNamayanja, Annette
dc.contributor.authorGosakan, Radhika
dc.contributor.authorMajeed, Tayyaba
dc.contributor.authorHart, Anna
dc.contributor.authorJafri, Hussain
dc.contributor.authorNardin, Juan
dc.contributor.authorCarroli, Guillermo
dc.contributor.authorFairlie, Fiona
dc.contributor.authorRaashid, Yasmin
dc.contributor.authorMirembe, Florence
dc.contributor.authorAlfirevic, Zarko
dc.date.accessioned2022-01-23T06:27:42Z
dc.date.available2022-01-23T06:27:42Z
dc.date.issued2010
dc.description.abstractRetained placenta is associated with post-partum hemorrhage. Meta-analysis has suggested that umbilical injection of oxytocin could increase placental expulsion without the need for a surgeon or anesthetic. We assessed the effect of high-dose umbilical vein oxytocin as a treatment for retained placenta. In this double-blind, placebo-controlled trial, hemodynamically stable women with a retained placenta for more than 30 min were recruited from 13 sites in the UK, Uganda, and Pakistan. 577 women were randomly assigned by a computer-generated randomization list stratified by center to 30 mL saline containing either 50 IU oxytocin (n=292) or 5 mL water (n=285), which was injected into the placenta through an umbilical vein catheter. All trial participants, study workers, and data handlers were masked to individual allocations. The primary outcome was the need for manual removal of the placenta. Analysis was by intention to treat. This study is registered, number ISRCTN 13204258.en_US
dc.identifier.citationWeeks, A. D., Alia, G., Vernon, G., Namayanja, A., Gosakan, R., Majeed, T., ... & Alfirevic, Z. (2010). Umbilical vein oxytocin for the treatment of retained placenta (Release Study): a double-blind, randomized controlled trial. The Lancet, 375(9709), 141-147. DOI:10.1016/S0140- 6736(09)61752-9en_US
dc.identifier.other10.1016/S0140- 6736(09)61752-9
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1449
dc.language.isoenen_US
dc.publisherThe Lanceten_US
dc.subjectUmbilical vein oxytocinen_US
dc.subjectTreatmenten_US
dc.subjectPlacentaen_US
dc.titleUmbilical vein oxytocin for the treatment of retained placenta (Release Study): a double-blind, randomised controlled trialen_US
dc.typeArticleen_US
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