The Anti-Mycobacterial Activity and Safety Profile of Selected Crinum Species in Northwestern Uganda

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dc.contributor.authorCandia, Milton
dc.contributor.authorKatuura, Esther
dc.contributor.authorWaako, Paul
dc.date.accessioned2021-12-12T12:52:33Z
dc.date.available2021-12-12T12:52:33Z
dc.date.issued2021
dc.description.abstractCrinum species is a source of many bioactive molecules with both antimicrobial and anti-tumor properties. Chloroform, methanol and aqueous extracts of Crinum scabrum and Crinum macowanii bulbs and leaves were investigated for their anti-mycobacterial activity against Mycobacteria tuberculosis using agar well diffusion, and broth dilution methods. Rifampicinstreptomycin resistant (R.S), pan African sensitive (H37Rv) and wild type (Sou 14827) strains of the bacteria were used. The investigation aimed to determine the anti-mycobacterial activity and safety profile of the crude extracts of Crinum scabrum and Crinum macowanii. The extracts had antimycobacterial activity that ranged between 1-5μg/ml. Their patterns of inhibition varied with the plant extract, solvent used for extraction and the organisms tested. Different concentrations of methanol extract were compared with similar concentrations of chloroform and aqueous extracts for their maximum zones of inhibition. All the extracts of Crinum macowanii were found inactive against Mycobacteria tuberculosis. Methanol leaf extract of Crinum scabrum was the most active, with minimum inhibitory concentration (MIC) less than1μg/ml and minimum bactericidal concentration (MBC) of 1μg/ml. acute toxicity test in mice for Crinum scabrum leaf was found to have LD50 greater than 2000mg/kg.en_US
dc.identifier.citationEngeu, O. P., Ralph, T., Moses, A., Gerosome, M., Kyeyune, G. N., Badru, G., & Paul, W. (2008). Repeat-dose effects of Zanthoxylum chalybeum root bark extract: a traditional medicinal plant used for various diseases in Uganda. African Journal of Pharmacy and Pharmacology, 2(8), 101-105.en_US
dc.identifier.issn2320-9186
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/351
dc.language.isoenen_US
dc.publisherAfrican Journal of Pharmacy and Pharmacologyen_US
dc.subjectTuberculosisen_US
dc.subjectCrinum scabrumen_US
dc.subjectCrinum macowaniien_US
dc.subjectMICen_US
dc.subjectMBCen_US
dc.subjectLD50en_US
dc.titleThe Anti-Mycobacterial Activity and Safety Profile of Selected Crinum Species in Northwestern Ugandaen_US
dc.typeArticleen_US
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