Feasibility of a large cohort study in sub-Saharan Africa assessed through a four-country study

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dc.contributor.authorDalal, Shona
dc.contributor.authorHolmes, Michelle D.
dc.contributor.authorLaurence, Carien
dc.contributor.authorBajunirwe, Francis
dc.contributor.authorGuwatudde, David
dc.contributor.authorNjelekela, Marina
dc.contributor.authorAdebamowo, Clement
dc.contributor.authorNankya-Mutyoba, Joan
dc.contributor.authorChiwanga, Faraja S.
dc.contributor.authorVolmink, Jimmy
dc.contributor.authorAjayi, Ikeoluwapo
dc.contributor.authorKalyesubula, Robert
dc.contributor.authorReid, Todd G.
dc.contributor.authorDockery, Douglas
dc.contributor.authorHemenway, David
dc.contributor.authorAdami, Hans-Olov
dc.date.accessioned2022-02-25T08:47:30Z
dc.date.available2022-02-25T08:47:30Z
dc.date.issued2015
dc.description.abstractLarge prospective epidemiologic studies are vital in determining disease etiology and forming national health policy. Yet, such studies do not exist in sub-Saharan Africa (SSA) notwithstanding the growing burden of chronic diseases. Objective: We explored the feasibility of establishing a large-scale multicountry prospective study at five sites in four sub-Saharan countries. Design: Based on country-specific considerations of feasibility, Nigeria enrolled health care professionals, South Africa and Tanzania enrolled teachers, and Uganda enrolled village residents at one rural and one periurban site each. All sites used a 6-month follow-up period but different approaches for data collection, namely standardized questionnaires filled out by participants or face-to-face interviews. Results: We enrolled 1415 participants from five sites (range 200489) with a median age of 41 years. Approximately half had access to clean-burning cooking fuel and 70% to piped drinking water, yet 92% had access to a mobile phone. The prevalence of chronic diseases was 49% among 45- to 54-year-olds and was dominated by hypertension (21.7% overall) ranging from 4.5 to 31.2% across sites and a serious injury in the past 12 months (12.4% overall). About 80% of participants indicated willingness to provide blood samples. At 6-month follow-up, 68% completed a questionnaire (45 to 96% across sites) with evidence that mobile phones were particularly useful. Conclusions: Our pilot study indicates that a large-scale prospective study in SSA is feasible, and the burden of chronic disease in SSA may already be substantial necessitating urgent etiologic research and primary prevention.en_US
dc.identifier.citationShona Dalal, Michelle D. Holmes, Carien Laurence, Francis Bajunirwe, David Guwatudde, Marina Njelekela, Clement Adebamowo, Joan Nankya-Mutyoba, Faraja S. Chiwanga, Jimmy Volmink, Ikeoluwapo Ajayi, Robert Kalyesubula, Todd G. Reid, Douglas Dockery, David Hemenway & Hans-Olov Adami (2015) Feasibility of a large cohort study in sub-Saharan Africa assessed through a four-country study, Global Health Action, 8:1, 27422, DOI: 10.3402/ gha.v8.27422en_US
dc.identifier.other10.3402/ gha.v8.27422
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/2305
dc.language.isoenen_US
dc.publisherGlobal Health Actionen_US
dc.subjectNon-communicableen_US
dc.subjectChronic diseaseen_US
dc.subjectInjuryen_US
dc.subjectSouth Africaen_US
dc.subjectNigeriaen_US
dc.subjectTanzaniaen_US
dc.subjectUgandaen_US
dc.titleFeasibility of a large cohort study in sub-Saharan Africa assessed through a four-country studyen_US
dc.typeArticleen_US
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