First Laboratory-Confirmed Outbreak of Human and Animal Rift Valley Fever Virus in Uganda in 48 Years

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dc.contributor.authorShoemaker, Trevor R.
dc.contributor.authorNyakarahuka, Luke
dc.contributor.authorBalinandi, Stephen
dc.contributor.authorOjwang, Joseph
dc.contributor.authorTumusiime, Alex
dc.contributor.authorMulei, Sophia
dc.contributor.authorKyondo, Jackson
dc.contributor.authorLubwama, Bernard
dc.contributor.authorSekamatte, Musa
dc.contributor.authorNamutebi, Annemarion
dc.contributor.authorTusiime, Patrick
dc.contributor.authorMonje, Fred
dc.contributor.authorMayanja, Martin
dc.contributor.authorSsendagire, Steven
dc.contributor.authorDahlke, Melissa
dc.contributor.authorKyazze, Simon
dc.contributor.authorWetaka, Milton
dc.contributor.authorMakumbi, Issa
dc.contributor.authorBorchert, Jeff
dc.contributor.authorZufan, Sara
dc.contributor.authorPatel, Ketan
dc.contributor.authorWhitmer, Shannon
dc.contributor.authorBrown, Shelley
dc.contributor.authorDavis, William G.
dc.contributor.authorKlena, John D.
dc.contributor.authorNichol, Stuart T.
dc.contributor.authorRollin, Pierre E.
dc.contributor.authorLutwama, Julius
dc.date.accessioned2022-04-28T19:58:14Z
dc.date.available2022-04-28T19:58:14Z
dc.date.issued2019
dc.description.abstractIn March 2016, an outbreak of Rift Valley fever (RVF) was identified in Kabale district, southwestern Uganda. A comprehensive outbreak investigation was initiated, including human, livestock, and mosquito vector investigations. Overall, four cases of acute, nonfatal human disease were identified, three by RVF virus (RVFV) reverse transcriptase polymerase chain reaction (RT-PCR), and one by IgM and IgG serology. Investigations of cattle, sheep, and goat samples from homes and villages of confirmed and probable RVF cases and the Kabale central abattoir found that eight of 83 (10%) animals were positive for RVFV by IgG serology; one goat from the home of a confirmed case tested positive by RT-PCR. Whole genome sequencing from three clinical specimens was performed and phylogenetic analysis inferred the relatedness of 2016 RVFV with the 2006–2007 Kenya-2 clade, suggesting previous introduction of RVFV into southwestern Uganda. An entomological survey identified three of 298 pools (1%) of Aedes and Coquillettidia species that were RVFV positive by RT-PCR. This was the first identification of RVFV in Uganda in 48 years and the 10th independent viral hemorrhagic fever outbreak to be confirmed in Uganda since 2010.en_US
dc.identifier.citationShoemaker, T. R., Nyakarahuka, L., Balinandi, S., Ojwang, J., Tumusiime, A., Mulei, S., ... & Lutwama, J. (2019). First laboratory-confirmed outbreak of human and animal rift valley fever virus in Uganda in 48 years. The American journal of tropical medicine and hygiene, 100(3), 659. doi:10.4269/ajtmh.18-0732en_US
dc.identifier.other10.4269/ajtmh.18-0732
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/2928
dc.language.isoenen_US
dc.publisherThe American journal of tropical medicine and hygieneen_US
dc.subjectLaboratoryen_US
dc.subjectHuman and Animal Rift Valley Fever Virusen_US
dc.subjectUgandaen_US
dc.subjectYearsen_US
dc.titleFirst Laboratory-Confirmed Outbreak of Human and Animal Rift Valley Fever Virus in Uganda in 48 Yearsen_US
dc.typeArticleen_US
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