The prevalence and clinical course of HIV-associated pulmonary cryptococcosis in Uganda

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dc.contributor.authorYoo, Samuel D.
dc.contributor.authorWorodria, William
dc.contributor.authorDavis, J. L.
dc.contributor.authorCattamanchi, Adithya
dc.contributor.authorBoon, Saskia den
dc.contributor.authorKyeyune, Rachel
dc.contributor.authorKisembo, Harriet
dc.contributor.authorHuang, Laurence
dc.date.accessioned2023-03-07T16:54:26Z
dc.date.available2023-03-07T16:54:26Z
dc.date.issued2010
dc.description.abstractThe prevalence and clinical course of pulmonary cryptococcosis in Sub-Saharan Africa are not well-described. Methods—Consecutive HIV-infected adults hospitalized at Mulago Hospital (Kampala, Uganda) between September 2007 and July 2008 with cough ≥ 2 weeks were enrolled. Patients with negative sputum smears for acid-fast bacilli were referred for bronchoscopy with bronchoalveolar lavage (BAL). BAL fluid was examined for mycobacteria, Pneumocystis jirovecii, and fungi. Patients were followed two and six months after hospital discharge. Results—Of 407 patients enrolled, 132 (32%) underwent bronchoscopy. Of 132 BAL fungal cultures, 15 (11%) grew Cryptococcus neoformans. None of the patients were suspected to have pulmonary cryptococcosis on admission. The median CD4 count among those with pulmonary cryptococcosis was 23 cells/μL (IQR 7–51). Of 13 patients who completed six-month follow-up, four died and nine were improved, including five who had started antiretroviral therapy (ART) but had not received antifungal medication. Conclusions—Pulmonary cryptococcosis is common in HIV-infected TB suspects in Uganda. Early initiation of ART in those with isolated pulmonary infection may improve outcomes, even without anti-fungal therapy. This finding suggests that some HIV-infected patients with C. neoformans isolated from respiratory samples may have colonization or localized infection.en_US
dc.identifier.citationYoo, S. D., Worodria, W., Davis, J. L., Cattamanchi, A., den Boon, S., Kyeyune, R., ... & Huang, L. (2010). The prevalence and clinical course of HIV-associated pulmonary cryptococcosis in Uganda. Journal of acquired immune deficiency syndromes (1999), 54(3), 269. doi:10.1097/QAI.0b013e3181ce6b19en_US
dc.identifier.other10.1097/QAI.0b013e3181ce6b19
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/8129
dc.language.isoenen_US
dc.publisherJournal of acquired immune deficiency syndromesen_US
dc.subjectPulmonary Cryptococcosisen_US
dc.subjectHIV/AIDSen_US
dc.subjectBronchoscopyen_US
dc.titleThe prevalence and clinical course of HIV-associated pulmonary cryptococcosis in Ugandaen_US
dc.typeArticleen_US
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