Vaccination with Recombinant Subolesin Antigens Provides Cross-Tick Species Protection in Bos indicus and Crossbred Cattle in Uganda
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Date
2020
Journal Title
Journal ISSN
Volume Title
Publisher
Vaccines
Abstract
Cattle tick infestations and transmitted pathogens a ect animal health, production and
welfare with an impact on cattle industry in tropical and subtropical countries. Anti-tick vaccines
constitute an e ective and sustainable alternative to the traditional methods for the control of tick
infestations. Subolesin (SUB)-based vaccines have shown e cacy for the control of multiple tick
species, but several factors a ect the development of new and more e ective vaccines for the control
of tick infestations. To address this challenge, herein we used a regional and host/tick species
driven approach for vaccine design and implementation. The objective of the study was to develop
SUB-based vaccines for the control of the most important tick species (Rhipicephalus appendiculatus, R.
decoloratus and Amblyomma variegatum) a ecting production of common cattle breeds (Bos indicus and
B. indicus x B. taurus crossbred) in Uganda. In this way, we addressed the development of anti-tick
vaccines as an intervention to prevent the economic losses caused by ticks and tick-borne diseases in
the cattle industry in Uganda. The results showed the possibility of using SUB antigens for the control
of multiple tick species in B. indicus and crossbred cattle and suggested the use of R. appendiculatus
SUB to continue research on vaccine design and formulation for the control of cattle ticks in Uganda.
Future directions would include quantum vaccinology approaches based on the characterization of
the SUB protective epitopes, modeling of the vaccine E under Ugandan ecological and epidemiological
conditions and optimization of vaccine formulation including the possibility of oral administration.
Description
Keywords
Cattle, Tick, Vaccine, Subolesin, Akirin
Citation
Kasaija, P. D., Contreras, M., Kabi, F., Mugerwa, S., & Fuente, J. D. L. (2020). Vaccination with recombinant subolesin antigens provides cross-tick species protection in Bos indicus and crossbred cattle in Uganda. Vaccines, 8(2), 319.