Cytochrome P450 2B6 (CYP2B6) G516T influences Nevirapine Plasma Concentrations in HIV-infected Patients in Uganda

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dc.contributor.authorPenzak, S.R.
dc.contributor.authorKabuye, G.
dc.contributor.authorMugyenyi, P.
dc.contributor.authorMbamanya, F.
dc.contributor.authorNatarajan, V.
dc.contributor.authorKityo, C.
dc.contributor.authorFormentini, E.
dc.contributor.authorMasur, H.
dc.date.accessioned2023-03-30T09:39:55Z
dc.date.available2023-03-30T09:39:55Z
dc.date.issued2007
dc.description.abstractPolymorphisms in the cytochrome P450 (CYP) 2B6 gene have been shown to influence nevirapine plasma concentrations in HIV-infected European Caucasians. Although nevirapine is used extensively in Africa, the influence of CYP2B6 genotype on nevirapine exposure has not been assessed in this population. We aimed to determine the influence of CYP2B6 genotype at position 516 on nevirapine trough concentrations in HIV-infected patients in Kampala, Uganda. Additional polymorphisms in the CYP and multidrug resistance protein-1 (MDR-1) genes were also assessed for their impact on nevirapine concentrations.en_US
dc.identifier.citationPenzak, S. R., Kabuye, G., Mugyenyi, P., Mbamanya, F., Natarajan, V., Alfaro, R. M., ... & Masur, H. (2007). Cytochrome P450 2B6 (CYP2B6) G516T influences nevirapine plasma concentrations in HIV‐infected patients in Uganda. HIV medicine, 8(2), 86-91.https://doi.org/10.1111/j.1468-1293.2007.00432.xen_US
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/8330
dc.language.isoenen_US
dc.publisherHIV medicineen_US
dc.subjectCYP2B6en_US
dc.subjectHIVen_US
dc.subjectNevirapineen_US
dc.subjectPharmacogenomicsen_US
dc.titleCytochrome P450 2B6 (CYP2B6) G516T influences Nevirapine Plasma Concentrations in HIV-infected Patients in Ugandaen_US
dc.typeArticleen_US
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