Diarrhoeagenic isolated from children with acute diarrhoea at Rakai hospital, Southern Uganda.

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dc.contributor.authorMasiga, Fredrick
dc.contributor.authorKigozi, Edgar
dc.contributor.authorNajjuka, Christine Florence
dc.contributor.authorKajumbula, Henry
dc.contributor.authorKateete, David Patrick
dc.date.accessioned2025-05-03T11:10:01Z
dc.date.available2025-05-03T11:10:01Z
dc.date.issued2022-03
dc.description.abstractBackground: Diarrhoeagenic Escherichia coli (DEC) is a leading cause of childhood diarrhoea. This study estimated the prevalence of DEC and DEC pathotypes among children with acute diarrhoea in Southern Uganda. Methods: A cross-sectional study was conducted on 267 children less than 5 years with acute diarrhoea, admitted to Rakai General Hospital in Southern Uganda. Faecal samples were collected from the children and processed for isolation of E. coli. The presence of DEC and the distribution of DEC pathotypes were determined by polymerase chain reaction. Results: A total of 102 (38.2%, 102/267) children had DEC of various pathotypes – enteroaggregative E. coli (EAEC) (14.2%); enteropathogenic E. coli (EPEC) (6.7%); enterotoxigenic E. coli (ETEC) (6%); enteroinvasive E. coli (EIEC) (7.5%); enterohemorrhagic E. coli (EHEC) (3%); and cell-detaching E. coli (CDEC) (0.75%). The difference in the overall prevalence of DEC was not significant regarding HIV but individually, EAEC and CDEC were associated with HIV-positive status while ETEC was associated with HIV-negative status. Conclusions: DEC is prevalent in children with acute diarrhoea in Southern Uganda and its identification in children should be considered among strategies for combatting childhood diarrhoea in Africa.
dc.identifier.citationMasiga F, Kigozi E, Najjuka CF, Kajumbula H, Kateete DP. Diarrhoeagenic Escherichia coli isolated from children with acute diarrhoea at Rakai hospital, Southern Uganda. Afri Health Sci. 2022;22(1):581-8. https://dx.doi.org/10.4314/ahs.v22i1.67
dc.identifier.other36032447
dc.identifier.urihttps://dx.doi.org/10.4314/ahs.v22i1.67
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/11356
dc.language.isoen
dc.publisherAfrican Health Sciences
dc.subjectChildhood diarrhea
dc.subjectDiarrhoeagenic Escherichia coli (DEC)
dc.subjectEnteroaggregative Escherichia coli (EAEC)
dc.subjectEnterohemorrhagic Escherichia coli (EHEC)
dc.subjectEnteroinvasive Escherichia coli (EIEC)
dc.subjectEnteropathogenic Escherichia coli (EPEC)
dc.subjectEnterotoxigenic Escherichia coli (ETEC)
dc.subjectEscherichia coli
dc.subjectRakai General Hospital
dc.subjectUganda
dc.titleDiarrhoeagenic isolated from children with acute diarrhoea at Rakai hospital, Southern Uganda.
dc.typeArticle
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