Does Adherence Change When No One is Looking? Comparing Announced and Unannounced Tenofovir Levels in a PrEP Trial

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dc.contributor.authorMusinguzi, Nicholas
dc.contributor.authorMuwonge, Timothy
dc.contributor.authorThomas, Katherine
dc.contributor.authorBaeten, Jared M.
dc.contributor.authorBangsberg, David R.
dc.contributor.authorHaberer, Jessica E.
dc.date.accessioned2023-02-07T19:11:19Z
dc.date.available2023-02-07T19:11:19Z
dc.date.issued2017
dc.description.abstractDifferences between unannounced and announced tenofovir levels as measures of PrEP adherence are not well understood. In an ancillary adherence study involving one urban site (Kampala) and two rural sites (Kabwohe and Tororo) from the Partners PrEP study, 268 specimen pairs from chronologically proximal clinic and home visits were tested for plasma tenofovir levels. Comparing clinic and home specimens, 89 versus 89 % were classified as detectable ([0.31 ng/ml; p = 0.77), 87 versus 86 % as recent dosing ([10 ng/ml; p = 0.80), and 82 versus 80 % as steady-state ([40 ng/ml; p = 0.44). Mean difference between announced and unannounced drug levels, adjusted for specimen collection time was 3.2 ng/ml (p = 0.50) for Kabwohe, 23.2 ng/ml (p = 0.003) for Kampala and -3.3 ng/ml p = 0.69) for Tororo. In the setting of high adherence, plasma tenofovir levels tested at the clinic were categorically similar as levels tested at home; however, differences were seen between urban and rural settings.en_US
dc.identifier.citationHaberer, J. E., Ngure, K., Muwonge, T., Mugo, N., Katabira, E., Heffron, R., ... & Baeten, J. M. (2017). Context matters: PrEP adherence is associated with sexual behavior among HIV serodiscordant couples in East Africa. Journal of acquired immune deficiency syndromes (1999), 76(5), 488. DOI 10.1007/s10461-016-1292-2en_US
dc.identifier.other10.1007/s10461-016-1292-2
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/7634
dc.language.isoenen_US
dc.publisherJournal of acquired immune deficiency syndromesen_US
dc.subjectAnnounced adherenceen_US
dc.subjectUnannounced adherenceen_US
dc.subjectPrepen_US
dc.subjectTenofoviren_US
dc.subjectEmtricitabineen_US
dc.titleDoes Adherence Change When No One is Looking? Comparing Announced and Unannounced Tenofovir Levels in a PrEP Trialen_US
dc.typeArticleen_US
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