Clausena anisata (Willd.) Hook.f. ex Benth. (Rutaceae): ethnomedicinal uses, phytochemistry, pharmacological activities, toxicity, and clinical application
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Date
2022
Journal Title
Journal ISSN
Volume Title
Publisher
Traditional Medicine Research
Abstract
Clausena anisata (Willd.) Hook.f. ex Benth. is a plant extensively used in traditional medicine.
Here, a synopsis of the research on various aspects of Clausena anisata (Willd.) Hook.f. ex Benth.
is presented. An electronic literature review revealed that formulations containing Clausena
anisata (Willd.) Hook.f. ex Benth. are used to manage and treat diabetes, eye problems, malaria,
snake envenomation, malignancies, as well as venereal, gastrointestinal, reproductive,
respiratory, dermatological, and odonatological ailments. To date, 90 compounds have been
isolated and characterized from extracts of Clausena anisata (Willd.) Hook.f. ex Benth. Crude
extracts and isolated compounds from Clausena anisata (Willd.) Hook.f. ex Benth. possess
anti-inflammatory, antimicrobial, antioxidant, antiplasmodial, antiproliferative, anti-human
immunodeficiency virus-1, antimycobacterial, antihypertensive, and antidiabetic activities.
These bioactivities can be attributed to alkaloids, coumarins, limonoids, and phenylpropanoids
present in different parts of the plant. Although some studies have indicated moderate toxicity
of the extracts, some of the dominant compounds in this species, such as estragole and
carbazole alkaloids, are mutagenic or cytotoxic. A clinical trial utilizing a Ghanaian herbal
formulation containing Clausena anisata (Willd.) Hook.f. ex Benth. was found to be effective in
reducing pain associated with osteoarthritis. Research progress to date supports the traditional
use of this species in herbal medicine. However, these studies do not explain the relationships
between traditional uses, pharmacological activities, and mechanisms of action. Thus, further
studies should be designed to understand the biochemical properties and physiological effects
of Clausena anisata (Willd.) Hook.f. ex Benth. extracts, facilitating the development and
utilization of this medicinal resource.
Description
Keywords
Carbazole alkaloid, Coumarin, Limonoid, Phenylpropanoid, Essential oil
Citation
Omara T, Kiprop AK, Kosgei VJ, Kagoya S. Clausena anisata (Willd.) Hook.f. ex Benth. (Rutaceae): ethnomedicinal uses, phytochemistry, pharmacological activities, toxicity, and clinical application. Tradit Med Res 2022;7(6):51. doi: 10.53388/TMR20220417001.