Dynamics Of Pre-Exposure (PrEP) Eligibility due to Waxing and Waning of HIV Risk in Rakai, Uganda

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dc.contributor.authorSsempijja, Victor
dc.contributor.authorSsekubugu, Robert
dc.contributor.authorKigozi, Godfrey
dc.contributor.authorNakigozi, Gertrude
dc.contributor.authorKagaayi, Joseph
dc.contributor.authorNalugoda, Fred
dc.contributor.authorNantume, Betty
dc.contributor.authorBatte, James
dc.contributor.authorKigozi, Grace
dc.contributor.authorNakawooya, Hadijja
dc.contributor.authorSerwadda, David
dc.contributor.authorReynolds, Steven J.
dc.date.accessioned2023-04-28T12:25:53Z
dc.date.available2023-04-28T12:25:53Z
dc.date.issued2022
dc.description.abstractWe conducted a retrospective population-based study to describe longitudinal patterns of prevalence, incidence, discontinuation, resumption, and durability of substantial HIV risk behaviors (SHR) for PrEP eligibility.The study was conducted among HIV-negative study participants aged 15-49 years that participated in survey rounds of the Rakai Community Cohort Study between August 2011 and June 2018. SHR was defined based on the Uganda national PrEP eligibility as either reporting sexual intercourse with >1 partner of unknown HIV status, non-marital sex without a condom or having transactional sex. Resumption of SHR meant resuming of SHR after stopping SHR, while persistence of SHR meant SHR on >1 consecutive visit. We used generalized estimation equations (GEE) with log-binomial regression models and robust variance to estimate survey-specific prevalence ratios (PR); GEE with modified Poisson regression models and robust variance to estimate incidence ratios for incidence, discontinuation, and resumption of PrEP eligibility.PrEP use should be tailored to the dynamic nature of PrEP eligibility. Preventive-effective adherence should be adopted for assessment of attrition in PrEP programs.en_US
dc.identifier.citationSsempijja, V., Ssekubugu, R., Kigozi, G., Nakigozi, G., Kagaayi, J., Ekstrom, A. M., ... & Reynolds, S. J. (2022). DYNAMICS OF PRE-EXPOSURE (PrEP) ELIGIBILITY DUE TO WAXING AND WANING OF HIV RISK IN RAKAI, UGANDA. JAIDS Journal of Acquired Immune Deficiency Syndromes, 10-1097.DOI: 10.1097/QAI.0000000000003182en_US
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/8574
dc.language.isoenen_US
dc.publisherJAIDS Journal of Acquired Immune Deficiency Syndromesen_US
dc.subjectWaxing and Waningen_US
dc.subjectPre-Exposureen_US
dc.subjectHIVen_US
dc.titleDynamics Of Pre-Exposure (PrEP) Eligibility due to Waxing and Waning of HIV Risk in Rakai, Ugandaen_US
dc.typeArticleen_US
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