Vitamin-D deficiency impairs CD4þT-cell count recovery rate in HIV-positive adults on highly active antiretroviral therapy: Q9 A longitudinal study

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dc.contributor.authorEzeamama, A.E.
dc.contributor.authorGuwatudde, D.
dc.contributor.authorWang, M.
dc.contributor.authorBagenda, D.
dc.contributor.authorKyeyune, R.
dc.contributor.authorSudfeld, C.
dc.contributor.authorManabe, Y.C.
dc.contributor.authorFawzi, W.W.
dc.date.accessioned2022-04-30T11:18:26Z
dc.date.available2022-04-30T11:18:26Z
dc.date.issued2015
dc.description.abstractWe implemented a prospective study among human immunodeficiency virus (HIV)- positive adults to examine the association between vitamin-D deficiency (VDD) and insufficiency (VDI) vs sufficiency (VDS) and CD4þT-cell improvement over 18 months of highly active antiretroviral therapy (HAART). Methods: We used data from a randomized placebo-controlled micronutrient trial with 25-hydroxy vitamin-D (25(OH)D) measured at enrollment in 398 adults. CD4þT-cell count was measured repeatedly at months 0, 3, 6, 12 and 18. Linear mixed models quantified the vitamin-D-related differences in CD4þT-cell count and associated 99% confidence intervals at baseline and respective follow-up intervals. Results: At baseline 23%, 60% and 17% of participants were VDS, VDI and VDD, respectively. Absolute CD4þT- cell counts recovered during follow-up were persistently lower for baseline VDD and VDI relative to VDS participants. The greatest deficit in absolute CD4þT-cells recovered occurred in VDD vs VDS participants with estimates ranging from a minimum deficit of 26 cells/ml (99% CI: 77, 26) to a maximum deficit of 65 cells/ml (99% CI: 125, 5.5) during follow-up. This VDD-associated lower absolute CD4þT-cell gain was strongest among patients 35 years old or younger and among participants with a baseline body mass index of less than 25 kg/m2. Conclusions: VDD is associated with lower absolute CD4þT-cell count recovery in HIV-positive patients on HAART. Vitamin-D supplementation may improve CD4þT-cell recovery during HAART. However, future intervention studies are needed to definitively evaluate the effectiveness of this vitamin as an adjunct therapy during HAART.en_US
dc.identifier.citationEzeamama AE, et al., Vitamin-D deficiency impairs CD4þT-cell count recovery rate in HIV-positive adults on highly active antiretroviral therapy: A longitudinal study, Clinical Nutrition (2015), http://dx.doi.org/10.1016/j.clnu.2015.08.007en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.clnu.2015.08.007
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/3050
dc.language.isoenen_US
dc.publisherClinical Nutritionen_US
dc.subjectVitamin-Den_US
dc.subjectHIVen_US
dc.subjectCD4þen_US
dc.subjectT-cell counten_US
dc.subjectAntiretroviral therapyen_US
dc.subjectImmune recoveryen_US
dc.titleVitamin-D deficiency impairs CD4þT-cell count recovery rate in HIV-positive adults on highly active antiretroviral therapy: Q9 A longitudinal studyen_US
dc.typeArticleen_US
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